ISSN: 2161-1149 (Printed)
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Department of Pediatrics, Cairo University, Cairo, Egypt
Research Article
Markers for Subclinical Inflammation in Egyptian Children with Familial Mediterranean Fever: Splenomegaly and Mean Platelet Volume
Author(s): Talaat HS, Sheba MF, Mohammed RH and Ibrahim MFM*
Background: Familial Mediterranean fever (FMF) is an auto-inflammatory systemic disease, of an autosomal recessive
inheritance, that is characterized by recurrent episodes of fever, peritonitis, pleuritis, pericarditis, and/or arthritis;
MEFV is the responsible gene.
Aim: To detect the correlation of Mean Platelet Volume (MPV) and splenomegaly as subclinical inflammatory
markers in children with FMF at the attack-free periods.
Methods: This cross-sectional study included 40 pediatric patients diagnosed clinically and according to gene
mutations already with FMF and were following-up at the Rheumatology Outpatient Clinic, Children's Hospital,
Cairo University. Abdominal ultrasonography was done all patients to detect splenomegaly; MPV was measured as
well.
Results: Patients was.. View More»
DOI:
10.35248/2161-1149.20.10.258