Journal of Cell Signaling
Open Access
ISSN: 2576-1471
ISSN: 2576-1471
The Hypertension & Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Graduated with BS, University of Memphis in 1974 and PhD, University of Tennessee - Memphis in 1983 and granted for Fellowship in University of Alabama - Birmingham, 1986 and acquirerd Memberships in American Physiological Society, Council For High Blood Pressure Research, American Association for Cancer Research, American Association of Advancement of Science, American Heart Association, American Society for Biochemistry and Molecular Biology and in Consortium for Southeastern Hypertension Control
and honoured with the Positions of Assistant Director for Hypertension and Vascular Research Center, Professor for Hypertension and Professor in Cancer Biology.
Research Article
The Microbiome Product Urolithin A Abrogates the TGF-β-EGFR-PAI-1 Pathway in NRK-52e Renal Epithelial Cells
Author(s): Chappell MC*, Pirro NT, Melo AC, Tallant EN and Gallagher PE
Ellagitanins are natural and complex polyphenolic compounds enriched in foods and commercial supplements. They are initially hydrolyzed to ellagic acid and further metabolized to urolithins by the gut microbiome. Ellagitanins are among a number of endogenous compounds found in fruits, nuts and vegetables that comprise a cardio protective diet for humans; however, biotransformation to urolithins may underlie their protective effects. Chronic treatment with urolithin A conveys anti-fibrotic and anti-inflammatory actions in experimental models of brain, cardiac, and kidney injury. Since the cellular actions and signaling events of urolithin A are undefined in renal cells, we assessed the influence of urolithin A on the TGF-β-PAI-1 pathway in NRK-52e cells, a well-characterized model of the proximal tubule epithelium and TGF-β induced signaling. TGF-β stimulated PAI-1 relea.. View More»
DOI:
10.35248/2576-1471.20.5.204