ISSN: 2736-6588
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Department of Gastroenterology, Mansoura University, Mansoura, Egypt
Research
Osteopontin Rs9138 and Rs1126616 Gene Polymorphism in Egyptian Patients with Colorectal Carcinoma
Author(s): Ehsan Rizk*, Mohammed El-Arman, Azza El-Baiomy, Tharwat Kandil, Shereen Mourad and Ola Elmam
Background: Osteopontin (OPN) is a glycophosphoprotein produced by a variety of cells and has several important
physiologic and pathologic roles including cancer pathogenesis through various signaling pathways. Genetic
polymorphisms of OPN in 3'UTR and exon may be implicated in the carcinogenesis and progression of colonic
carcinomas.
Objectives: This study aimed to find whether OPN rs9138 and rs1126616 single nucleotide polymorphisms were
associated with increased risk and progression of Colorectal Carcinoma (CRC).
Subjects and methods: Randomized case control study conducted on 100 CRC patients and 100 apparently
healthy subjects. All subjects were investigated for OPN rs9138 and rs1126616 genotyping and CEA, CA 19-9 and
OPN plasma levels. The genotypes were assayed using Polymerase Chain Reaction-R.. View More»
DOI:
10.35248/JCCLM.22.5.238