Drug Designing: Open Access
Open Access
ISSN: 2169-0138
ISSN: 2169-0138
Department of Marine Science, Mawlamyine University, Taung Wine Rd, Mawlamyine, Myanmar
Short Communication
Molecular Docking of Carrageenans for Main Protease (Mpro) and Angiotensin-Converting Enzyme 2 (ACE2) of SAR-COV-2
Author(s): Thet Htwe Aung*
The World Health Organization (WHO) has classified COVID-19 as a pandemic infection due to the global spread
of new corona virus infections. Due to this virus infection, millions of people all around the world had to die or
endure severe disease. To prepare for a comparable viral pandemic in the future, it will be imperative to discover
new therapeutic treatments. Carrageenans have apparently been effective against 12 viruses, including SAR-COV-2.
In this investigation, Main Protease (Mpro) and Angiotensin-Converting Enzyme 2 (ACE2) were used as molecular
targets for virtual screening of kappa-, lambda-, and iota- carrageenans. When compared to antiviral drugs, the
results show that all three carrageenans have substantial binding affinity for ACE2 and Mpro. The binding affinity
of iota-carrageenan is greater than that of other compounds. The binding affinity sugge.. View More»
DOI:
10.35248/2169-0138.22.11.221