Journal of Sleep Disorders & Therapy
Open Access

Synthonics Inc., Blacksburg, VA, United States

Publications

• Original Research Article   
  Topical Magnesium- Coordinated Cannabidiolic Acid (CBDA) for the Treatment of Restless Leg Syndrome
  Author(s): Debra Kimless*, Thomas Piccariello and Jabari Byrd
  
  Topical Magnesium-Coordinated Cannabidiolic Acid (CBDA) for the Treatment of Restless Leg Syndrome Restless Leg Syndrome (RLS) is multifactorial disease state with many different potential pathophysiological mechanisms, which includes iron deficiency, dysfunctions from the cerebral cortex and spinal cord to mechanosensitive channels at the musculoskeletal periphery. Most therapeutic agents effectiveness focuses on the central nervous system (e.g., dopaminergic drugs) or Renshaw cells. There are virtually no effective therapeutic agents that are focused on the periphery. We hypothesize that treatment for RLS can focus on the peripheral musculoskeletal component of the disease, more specifically the mechanosensitive channels such as Piezo 2 and TRPA1. We conducted an open-label IRB-approved clinical trial using a proprietary topical preparation of our magnesium-coordinated CBDA to explo.. View More»
  DOI: 10.35248/2167-0277.25.14.623

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