Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Department of Urology, Akita University School of Medicine, Akita, Japan
Research Article
A Novel Research Area of PCDH-PC in Inhibition of Prostate Cancer Cells Invasion and Metastasis through Epithelial: Mesenchymal Transition
Author(s): Xuezhen Yang*, Xu Jiang, Xueping Ma, Tomonori Habuchi and Yinglu Guo
Objective: To evaluate the effects of Protocadherin-PC (PCDH-PC) gene expression on Epithelial Mesenchymal
Transition (EMT) in prostate cancer cells.
Methods: Western blot analysis, morphological analysis, and in vitro wound closure assay were used to assess the
effects of inhibition of PCDH-PC expression on EMT in the androgen-independent prostate cancer cell lines DU-
145 and PC-3.
Results: Inhibition of PCDH-PC expression promoted Mesenchymal Epithelial Transition (MET) of DU-145 and
PC-3 cells, which changed the cytomorphology to resemble that of the androgen-dependent prostate adenocarcinoma
cells LNCaP, and slowed down the growth rate.
Conclusions: Inhibition of PCDH-PC expression reduced the invasiveness of androgen-independent prostate cancer
cells... View More»
DOI:
10.35248/2471-9552.20.6.164