Journal of Cancer Research and Immuno-Oncology
Open Access
ISSN: 2684-1266
+44-20-4587-4809
ISSN: 2684-1266
+44-20-4587-4809
Center of Excellence for Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania
Research
The Immune Response in Gastrointestinal Stromal Tumors
Author(s): Vlad Herlea*, Alexandra Rosulescu, Andreea Iorgescu, Simona Olimpia Dima, Traian Dumitrascu, Vladislav Brasoveanu, Cezar Stroescu, Catalin Vasilescu and Irinel Popescu
Background: Gastrointestinal stromal tumors (GISTs) are the most frequent tumors with mesenchymal origin at the
level of the digestive tract. Assessment of intratumoral immune cells can provide valuable prognostic information
and may contribute to the development of targeted immune therapies for selected cases. Here in we evaluated the
inflammatory infiltrate in gastrointestinal stromal tumors, the ratios between cytotoxic and helper T cells and their
prognostic significance.
Methods: We retrospectively analysed 25 cases of GISTs and extragastrointestinal stromal tumors (EGISTs).
Immunohistochemical testing for CD3, CD4, CD8, CD20 and CD68 was performed to emphasize the immune
cells. Inflammatory cells were quantified with the help of ImageJ software. Statistical analysis was performed to
search for correlation between the.. View More»
DOI:
10.35248/2684-1266.20.6.125