Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Department of Health Care Informatics, Harrisburg University, Pennsylvania, USA
Research Article
Network Pharmacology and Molecular Docking Reveals Spinacia oleracea Constituents as Potential Pulmonary Arterial Hypertension (PAH) Therapeutics
Author(s): Yenumala Vamshidhar Reddy*, Thogaru Thanish Varma and Varikuppala Anand
Spinacia oleracea is a very famous medicinal plant that bears a lot of biological activities. The high pressure in the pulmonary arteries, which is a dangerous unhealthy condition leading to heart failure and finally death, is called Pulmonary Arterial Hypertension (PAH). Hence, in the current study, there was an attempt to probe into possible active constituents of spinach with the use of network pharmacology and molecular docking in the treatment of PAH. The results identified the common targets between spinach constituents and PAH-related proteins, including hub targets such as Epidermal Growth Factor Receptor (EGFR), Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), Sarcoma Proto-Oncogene (SRC) and Matrix Metalloproteinase 9 (MMP9). Pathway analysis revealed association with lipid metabolism, atherosclerosis and the Interleukin 17 (IL-17) signali.. View More»