Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Animal Nutrition, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu, India
Research Article
Synthesis, Characterization and Potential Studies of Peptide Loaded Chitosan Coated (PLCC) and Sodium Alginate (SA) Nanoparticles
Author(s): Dharmar Manimaran and Vasan Palanisamy*
Peptide Loaded Chitosan Coated (PLCC) and Sodium Alginate (SA) nanoparticles are considered as an effective deliver therapeutic molecules to the target site. PLCC and SA nanoparticles were synthesized by the ionic gelation process and their peptide polymer compatibilities were analysed by Fourier Transform-Infrared Spectroscopy (FT-IR) and X-Ray Diffraction (XRD). Nanoparticles (NPs) morphology Scanning Electronic Microscope (SEM), process yield, association and loading efficiency, in vitro peptide release, size distribution and zeta potentials, kinetic modelling, haemocompatibility, plasma stability, genotoxicity and embryo toxicity studies were performed by using Danio rerio model. High peptide polymer compatibility was high in PLCC than the SA nanoparticles. X-ray diffraction proved that the peptide had been loaded perfectly in the chitosan nanoparticles.. View More»
DOI:
10.35248/2736-6588.24.7.291