Journal of Leukemia
Open Access
ISSN: 2329-6917
+44 1300 500008
ISSN: 2329-6917
+44 1300 500008
Parasitology Research Laboratory, Children's Hospital of Mexico Federico Gómez, Dr. Márquez 162, Col Doctores, Cuauhtemoc 06720, CdMx, Mexico
Research Article
Trypanosoma cruzi Antigenic Proteins: Shared with Acute Lymphoblastic Leukemia and Neuroblastoma
Author(s): Leticia Eligio García, Mariana Soria Guerrero, María del Pilar Crisóstomo Vá, Víctor Alberto Maravelez Acosta, Adrián Cortes Campos and Enedina Jimenez Cardoso*
An inhibitory relationship has been reported between the incidence of some parasitic infections and the development of cancer. Reported studies show that immunization with protein extracts of T. cruzi, the protozoan parasite that causes Chagas disease, prevents the appearance of tumors in 60% of mice injected with the murine lung carcinoma tumor line. The molecular bases of this process have not been elucidated, although the presence of antigens present in tumor cells and on the surface of T. cruzi suggests an anti-parasitic immune response with an effective cross-reaction against cancer cells, hence the importance to identify the antigens involved and figure out their potential as target cells in anticancer therapy. The general objective of this work is to determine the presence of antigenic proteins of T. cruzi, shared with cells in culture of ALL and NB,.. View More»
DOI:
10.35248/2329-6917.22.10.307