ISSN: 2736-6588
Dr. A.P.J. Abdul Kalam Centre for Excellence in Innovation & Entrepreneurship, Dr. M.G.R. Educational and Research Institute, Maduravoyal, Chennai 600095, India
Research Article
Analysis of Moonlighting Proteins Regulated by Curcumin and Resveratrol in Cancer
Author(s): Venil N. Sumantran* and Anand Babu Kannadasan
Multitasking Proteins or Moonlighting Proteins (MLP) play a major role in human disease and many are drug
targets. MLPs have a single polypeptide with two different biochemical functions and often have different cellular
localizations. Analysis of MultitaskProtDB-II and comparative toxicogenomics databases and Gene Ontology (GO)
and STRING analysis, showed that curcumin and resveratrol regulate 3 groups of MLPs. Group 1 MLPs drive
Epithelial Mesenchymal Transition (EMT), whereas MLPs in groups 2 and 3 regulate tumor growth and suppression,
respectively. The 3 groups of MLPs form a complex self-regulating network due to regulatory interactions between
MLPs and the presence of transcription factors (CTNNB1, p53, NRF2) with their regulators and targets. Curcumin
and/or resveratrol downregulate MLPs which drive EMT (CTNNB1, FASN, SMADs 2,3,4, MECP2, MMP2,
TGFჅ.. View More»
DOI:
10.35248/2736-6588.23.6.274