Lupus: Open Access
Open Access

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine “Guido Baccelli”, University of Bari Medical School, Italy

Biography

He belongs from Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine “Guido Baccelli” in University of Bari Medical School at \ Bari, Italy. His Subjects of Specialization are Biomedical Sciences, Human Oncology, Lymphocytes,Cytokines, Development biology, Flow Cytometry,Immunity,

Publications

• Research   
  Early Echocardiographic Detection of Left Ventricular Diastolic Dysfunction in Patients with Systemic Lupus Erythematosus Asymptomatic for Cardiovascular Disease
  Author(s): Patrizia Leone, Sebastiano Cicco, Marcella Prete, Nicola Susca, Lucilla Crudele, Alessio Buonavoglia, Paolo Colonna, Franco Dammacco*, Angelo Vacca and Vito Racanelli*
  
  Cardiovascular disease (CVD) is a major complication of systemic lupus erythematosus (SLE) and is now a leading cause of death for these patients. In this study, 23 SLE patients asymptomatic for CVD underwent a comprehensive echocardiographic examination to detect subclinical cardiac involvement. According to their SELENA-SLEDAI score, they were divided into two groups: SELENA-SLEDAI ≤ 12 (n=13, 12 females) and SELENA-SLEDAI >12 (n=10, all females), indicative of mild to moderate and severe SLE, respectively. Patients in the latter group had significant increases in left ventricular (LV) mass, LV end-diastolic volume, left atrial volume and right heart parameters (pulmonary arterial pressure, tricuspid regurgitation velocity and diameter of the inferior cava) compared to the mild-moderate group. Diastolic dysfunction, evaluated as the early/late (E/A) and early/septal velocity (.. View More»
  

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