Journal of Women's Health Care
Open Access
ISSN: 2167-0420
ISSN: 2167-0420
Department of Community Medicine, Federal Medical Centre, Makurdi, Benue State, Nigeria
Research Article
Comparison of the Effectiveness of 2.5mg versus 5mg Doses of Letrozole for Ovulation Induction in Infertile Women with Polycystic Ovarian Syndrome: A Non-Randomized Control Trial
Author(s): Omoregie Irowa*, Paulinus Abu, Hameed Mohammad, Vivian Nguyan Shaahu, Michael Adakole Obulu, Silas Ochejele, Franklin Emeke Osagie and Stephanie Erdoo Chenge
Background: Polycystic ovarian syndrome (PCOS) accounts for over 75% of anovulatory infertility. Letrozole is an effective alternative to clomiphene citrate as a first-line drug for ovulation induction in women with PCOS. This study aims to compare the effectiveness and safety profile of 2.5mg to 5mg daily oral doses of letrozole for ovulation induction in infertile women with PCOS.
Methods: The study was a nonrandomized control trial (NRCT). One hundred and ten eligible consenting infertile women with PCOS were consecutively assigned into two treatment groups. The intervention group received oral letrozole 2.5mg daily and the control group received oral letrozole 5mg daily, both groups starting from the 2nd day of menses for 5 days. Participants in both groups were followed up to determine the primary and secondary outcome measures. Data we.. View More»
DOI:
10.35248/2167-0420.23.12.626