Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-77-2385-9429
ISSN: 2157-7609
+44-77-2385-9429
Department of Isotope Applications, Institute of Nuclear Energy Research, Taoyuan, Taiwan
Research Article
Metabolism Study of Fluor-Nitrophenylallylideneindolinone Ligand: A Radioimaging Agent for False Folded Alpha-Synuclein in the Diagnosis of Parkinson's Disease by High-Performance Liquid Chromatography and Tandem Mass Spectrometry
Author(s): Weihsi Chen*, Kuanyin Chen, Tsungyu Shih, Siaosyun Guan and Shioushiow Farn
Background: The false folded protein of alpha (α) synuclein forms aggregation and causes neurodegenerative diseases
known as α-synucleinopathies, such as Parkinson's disease. A radioactive fluor- labeled ligand, (Z)-{(fluoroethoxy)
ethyl}-(E)-3-(4-nitrophenyl)-allylidene]-indolin-2-one (αsyn-18F), was synthesized and tested as a Positron Emission
Tomography (PET) imaging agent for use in animal studies for the diagnosis of α-synucleinopathies.
Aim: To assess the synthetic products qualities of α-syn-F standard and its precursor, α-syn-Ms (Ms: methanesulfonate),
determine the attendant impurities, and metabolites of α-syn-F in plasma, liver and brain biosystems.
Methods: Various sample solutions were analyzed via High-Performance Liquid Chromatography (HPLC) on a C18.. View More»
DOI:
10.35248/2157-7609.22.13.270