Department of Hematology, Fujian Provincial Hospital, Fuzhou 350000, China
Research Article
The Clinical Value of Circulating Cell Free DNA in Multiple Myeloma
Author(s): Tong Yang, Yun Lin*, Weimin Chen, Zhihong Wang, Tiannan Wei and Jin Shang
Purpose: To evaluate the feasibility of the detection of circulating cell free DNA (cfDNA) and the prognostic value
of cfDNA in patients with Multiple Myeloma (MM).
Experimental design: All samples were screened hematopoietic malignancy associated genetic mutations from
cfDNA and Bone Marrow (BM), using the Next Generation Sequencing (NGS). The mutated genetic, checked in
both cfDNA and BM, were monitored at the different time points during the treatment by droplet-based digital
PCR (ddPCR).
Results: Three patients were included in our prospective study. Two patients detected DNMT3A mutations and one
patient detected GNAQ mutation. The abundance of mutations decreased as the disease remission, and increased
as the disease progresses. The detection of cfDNA has shown to predict relapses before paraprot.. View More»
DOI:
10.35248/IGOA.22.7.174