Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Orthopedics, The First Clinical Medical College of Guangzhou University of Chinese Guangzhou, Guangzhou, China
Research Article
Analysis of Integrating PIK3CA and NF1 Mutations into Glioblastoma Multiforme Prognostication and Immunotherapy Treatment Strategy
Author(s): Lin Xie*, Anmin Liu*, Qinbiao Chen, Min Luo, Linlin Lu, Wenjing Lin and Cheng Zhong
Objective: The potential mechanisms of NF1, Phosphatidylinositol-4,5-bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA) and Neurofibromatosis 1 (NF1) expressions in Glioblastoma Multiforme (GBM) have been poorly elucidated. Risk-score analysis combined with clinic pathological characteristics to assess the prognostic value and immunotherapy efficacy of 6-genes signature.
Methods: We performed the whole exosome sequencing profiling on samples form patients with GBM. The association of PIK3CA and NF1 expression within the GBM have received cross-validations by Mendelian Randomization (MR) methods and the risk-score analysis of 6-gene signature.
Results: MR study demonstrated that PIK3CA and NF1 expressions were closely related with the risk of GBM patient.. View More»
DOI:
10.35248/2736- 6588.24.7.287