Immunotherapy: Open Access
Open Access

Emergency Intensive Care Unit, Guizhou Provincial People's Hospital, Guizhou, China

Publications

• Research Article   
  Early Mixed Inflammatory Response in Children with Sepsis
  Author(s): Cen Li, Xia Lv, Xia Fan, Dong Huang* and Jianquan Li*
  
  Objective: By dissecting systemic inflammatory response, we aimed to provide the reference to treatment for pediatric patients with sepsis. Methods: 62 pediatric children with sepsis and 48 pediatric children without sepsis were enrolled in study. HLA- DR/CD14+ expression, proportion of CD4+CD25+ Forkhead box protein P (Foxp3+) Treg cells and IL-27+, CD4+ cells were analyzed by flow cytometry. Foxp3, CTLA-4, GITR, IL-10, L-17A, IL-17F and IL-27 mRNA levels were evaluated by real-time PCR. IL-4, IFN-γ and TGF-β were measured by enzyme-linked immunosorbent assay. Results: Compared to children without sepsis, there are higher level of IFN-γ, IL-17A, IL-17F, IL-27 mRNA, Foxp3, CTLA-4, IL-10 mRNA and proportion of CD4+, IL-27+ cells and lower of TGF-β and CD4+CD25+Treg cells in children with sepsis.. View More»
  DOI: 10.35248/2471-9552.24.10.247

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