Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Institute of Hematology, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China
Research Article
Characterization of Aging-Related Profiles in Esophageal Cancer Reveals a Signature Predicting Favorable Outcome and Immunogenicity
Author(s): Hui Cheng, ChongMei Huang, HuiYing Qiu, WeiPing Zhang, Li Chen, XianMin Song, JianMin Yang and JianMin Wang*
Background: It has been revealed that aging plays crucial roles in tumorigenesis, prognosis, and therapy response of
tumors including esophageal carcinoma (ESCA). In this work, we aim to establish an aging-relevant risk signature to
assess the survival outcome and immunogenicity status of ESCA patients.
Methods: A total of 351 ESCA patients with both gene expression data and clinical information from 3 independent
datasets were curated. The Lasso-Cox regression model was applied to identify the aging genes that contributed most
to the survival outcome. The risk signature was constructed by combining the specific gene expression level with
the corresponding regression coefficients. Microenvironment-based immunologic factors, mutational burden, and
significantly mutated genes were evaluated based on the identified risk groups. .. View More»
DOI:
10.4172/2167-7700.22.10.158