ISSN: 2157-7013
+44 1300 500008
Institute of Brain Science, Shanxi Datong University, Datong, 037009, China
Mini Review
A Recently Discovered Essential Factor for DNA Homologous Recombination:
RNA Polymerase III
Author(s): Sijie Liu*, Xiaoqin Liu and Daochun Kong*
End resection is a central step in DNA homologous recombination (HR) and the HR-mediated repair of DNA
double-strand breaks (DSBs), which degrades 5’-end strands at DSBs by several kilo-bases and thus creates 3’-end
single-strand DNA overhangs. A critical long-standing question is how the 3’-end strands are protected during end
resection. Now, this question is answered. Liu et al. found that the protection of 3’-end strands is achieved by the
formation of an RNA-DNA hybrid. RNA polymerase III is responsible for catalyzing the RNA strand in the hybrid.
Thus, RNA polymerase III is an essential factor for HR, and the RNA-DNA hybrid is an essential HR intermediate... View More»
DOI:
10.35248/2157-7013.21.12.302