Journal of Depression and Anxiety
Open Access
ISSN: 2167-1044
ISSN: 2167-1044
Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People’s Republic of China, School of Public Health, Health Science Center, Xi’an Jiaotong University, X, China
Research Article
Identifying Candidate Proteins and Chemicals for Age at First Episode of Depression and Postpartum Depression
Author(s): Feng Zhang*, Na Zhang, Zhen Zhang, Shiqiang Cheng, Yumeng Jia, Yan Wen, Xiaoyue Qin, Dan He, Wenming Wei, Yijing Zhao, Qingqing Cai, Sirong Shi and Xiaoge Chu
Background: Depression is not only the leading cause of disability worldwide. Limited studies have been conducted
to explore the proteins and chemicals associated with Age at First Episode of Depression (AFED) and Postpartum
Depression (PPD) from genetic perspective.
Methods: The Polygenic Risk Score (PRS) of 130 brain proteins, 262 plasma proteins and 404 Cerebro Spinal
Fluid (CSF) proteins were first calculated utilizing the genotype data from the UK Biobank. Pearson correlation
analysis was then conducted to test the association of each protein PRS with AFED and PPD in UK Biobank.
Based on chemical-gene interaction data of The Comparative Toxicogenomics Database (CTD), we also conducted
enrichment analysis to identify the chemicals associated with depression-related proteins.
Results: Pearson corre.. View More»
DOI:
10.35248/2167-1044.22.11.480