Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Dr, Department of Oral and Maxillofacial Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
Research Article
Pan-Cancer Analysis Identifies SEC11A as an Immunological and Prognostic Biomarker
Author(s): Qingqing Wu, Chengdong Liu, Guangzhao Huang, Xinyan Lu, Xiaozhi Lv* and Tingru Shao*
Objective: Limited evidence suggests a vital role for SEC11A in carcinogenesis. Our study conducted an integrated analysis on the molecular features and clinical relevance of SEC11A across pan-cancer based on multi-omics data.
Materials and methods: SEC11A expression was analyzed in 33 types of tumor and normal specimens utilizing transcriptome profiles from The Cancer Genome Atlas-Genotype-Tissue Expression (TCGA-GTEx) project and protromic data from Clinical Proteomic Tumor Analysis Consortium (CPTAC) project. Copy number alterations and methylation of SEC11A were investigated across pan-cancer with cBioPortal. Clinical relevance and prognostic implications of SEC11A were evaluated in The Cancer Genome Atlas (TCGA) cohorts. Gene Set Enrichment Analysis (GSEA) of SEC11A was conducted in Head and Neck Squamous Cell Carcinoma (HNSCC).. View More»
DOI:
10.35248/2167-7700.23.11.199