Immunotherapy: Open Access
Open Access

Department of Oncology, First People's Hospital of Xinxiang and The Fifth Affiliated Hospital of Xinxiang Medical College, Street Yiheng 63, Xinxiang, China

Publications

• Research Article   
  Monastrol Targeted KIF11 Showed Potential Treatment Effective of Small Cell Lung Cancer
  Author(s): Xiaye Lv*, Xinhui Wang, Pengcheng Zhou, Shanshan Jiang, Baolin Zhou, Haoqun Xie, Bo Yu and Yuanyuan Hou
  
  Object: This study is to identify Small Cell Lung Cancer (SCLC) driver genes, annotate enrichment functions and key pathways, and also verify Monastrol therapeutic effect. Methods: The gene expression profiles of GSE40275 and GSE43346 was analyzed to identify the DEGs (Differentially Expressed Genes) between SCLC and the normal tissue. GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis and PPI (Protein-Protein Interaction) network analysis were conducted to find out the enrichment functions, pathways and hub genes. Moreover, in vitro, MTT assay, colony-forming assay, and the scratch assay were performed to verify the effect of Monastrol. Results: There were common 129 up-regulated and 176 down-regulated DEG’s between SCLC samples and normal lung samples. KIF11, NDC80,.. View More»
  DOI: 10.35248/2471-9552.22.8.195

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