Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Department of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang, China
Research Article
HFE Gene Regulation of T-lymphocyte Activity Can be a Potential Target of PCOS
Author(s): Qi Xu*, Yu-Hang Song, Ya-Nan Chen, Bin-Lu Wang, Guo-Qing Du and Yao Li
Poly-Cystic Ovary Syndrome (PCOS) may be characterized by skeletal muscle abnormalities. Pioglitazone has a certain therapeutic effect on skeletal muscle metabolism in PCOS patients. To investigate the other effects of pioglitazone on skeletal muscle and its mechanism. We used Weighted Gene Co-expression Network Analysis (WGCNA) to identify potential key genes and signaling pathways involved in pioglitazone affecting skeletal muscle in PCOS patients. First, download the chip data of GSE8157 from GEO database. Then, modules related to genes expressed in skeletal muscle of PCOS patients before and after pioglitazone treatment were screened by WGCNA and core genes and differential gene analysis methods were further selected according to the correlation characteristics between modules and clinical manifestations. Finally, the selected genes were enriched for analysis. Four sign.. View More»
DOI:
10.35248/2471-9552.22.08.206