ISSN: 2167-0870
+44 1478 350008
Department of Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi’an, China
Research Article
Identification of Methylation Driven Biomarkers for Diagnosis and Prognosis in Colorectal Cancer by Integrative Analysis of TCGA, GTEx, and GEO Database
Author(s): Lichao Cao, Ying Ba, Jin Yang* and Hezi Zhang*
Background: This work investigates the use of methylation driven biomarkers for diagnosis and prognosis in Colorectal Cancer
(CRC) by mining DNA methylation and gene expression data from The Cancer Genome Atlas (TCGA), the Genotype-Tissue
Expression project (GTEx), and the Gene Expression Omnibus (GEO).
Methods: The Differentially Expressed Genes (DEGs) and Differentially Methylated Genes (DMGs) were screened using
mRNA expression and DNA methylation data from TCGA, respectively. The Methylation Driven Genes (MDGs) of CRC were
further identified using the MethylMix R package. Subsequently, the MDGs were analyzed with Random Forest (RF), Support
Vector Machine (SVM), and Logistic Regression (LR) algorithms to establish diagnosis prediction models as independent
indicators using mRNA expression data from TCGA and GTEx. The RF a.. View More»
DOI:
10.35248/2167-0870.22.S16.003