Internal Medicine: Open Access
Open Access

Department of Pharmacy, Guilin Medical University, Guilin 541004, People's Republic of China

Publications

• Research Article   
  Extract from Polygala Fallax Hemsl. Protects Kidneys in db/db Mice by Inhibiting the TLR4/MyD88/NF-?B Signaling Pathway
  Author(s): Yukun Bao, Zeyue Wang, Qing Xu, Lixin Wang, Yi Wen, Peng Deng* and Qin Xu*
  
  Diabetic Nephropathy (DN) is a chronic kidney disease caused by the loss of renal function. The Extract of Polygala Fallax Hemsl (EPF) possesses anti-inflammatory and other pharmacological effects. Objective: To investigate the effect and potential mechanism of Extract of Polygala Fallax Hemsl (EPF) in the treatment of diabetic nephropathy-associated inflammation. Materials and methods: Db/db mice were administered varying doses of EPF (15, 30, 60 mg/kg), after which the kidney organ index and glucose tolerance were calculated. Urine micro albumin was detected in urine collected over 24 hours. Serum FBG, Cr, and BUN levels were measured, and H&E and PAS staining were used to observe pathological changes in the kidney. The expression of TLR4, MyD88, NF-κB, and MMP-9 in kidney tissue was measured using immunohistochemistry,.. View More»
  DOI: 10.35248/2165-8048.23.13.433

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