Journal of Probiotics & Health
Open Access
ISSN: 2329-8901
ISSN: 2329-8901
Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan
Research Article
Lactiplantibacillus plantarum TCI999 Probiotic Promoted Hair Growth and Regulated Gut Microbiome: Double-Blind, Placebo-Controlled Trial
Author(s): Chia-Hua Liang, Yung-Hsiang Lin, Shu-Ting Chan, Yung-Kai Lin* and Chi-Fu Chiang*
Lactiplantibacillus plantarum is widely used as a probiotic and had increase hair growth in vitro. However, it is still unclear whether L. plantarum can improve hair loss and gut microbiome in clinical trial. The purpose of this study is to examine the effect of L. plantarum on inhibiting hair loss, strengthening hair roots, improved gut microbiome. TCI999 (L. plantarum) was used to treat human Hair Follicle Dermal Papilla Cells (HFDPC), and examine mitochondrial activity and viability of hair follicle cells, and examined hair follicle growth inhibition-related genes (SRD5A1, AR and TGF-β). Additionally, 50 subjects were recruited, and divided into a placebo group and TCI999 group. It was taken once a day for 12 weeks, followed by hair testing, hair-related genes analysis, collection of hair loss and.. View More»
DOI:
10.35248/2329-8901.22.10.285