ISSN: 1745-7580
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Department of Biochemistry Federal University Gusau, Zamafara State, Nigeria
Yusuf Muhammed is affiliates from the department of biochemistry federal university gusau, Zamafara State, Nigeria. The author research and interests in antibody drugs and biochemistry
Review Article
The Best IgG Subclass for the Development of Therapeutic Monoclonal Antibody Drugs and their Commercial Production: A Review
Author(s): Yusuf Muhammed*
Most of the clinically available monoclonal antibody (mAbs) drugs are Immunoglobulin G's (IgG's). The variability of
the IgG subclasses is in the amino acid content of the hinge region which forms the basis of their stability and
suitability for therapeutics development. Monoclonal antibody drug development is a tedious and long-term process
requiring putting many factors into consideration. The variability in the stability, flexibility, mediation of antibody
dependent cell cytotoxicity (ADCC), mediation of cellular dependent cytotoxicity (CDC), and C1q protein binding
are major factors that determine the suitability of IgG subclasses for the development of therapeutics. It was reviewed
that most of the marketed mAbs therapeutics are IgG1 subclass, this is due to its stability and less aggregate
formation, triggering of effector function via the action of Fc domai.. View More»
DOI:
10.35248/1745-7580.20.16.173