Immunotherapy: Open Access
Open Access

Shenzhen International Institute for Biomedical Research, 140 Jinye Ave. Building A10, Dapeng New District, Shenzhen, Guangdong 518116, China

Biography

Dr. Tang Yuxin is a Professor in the School of Chemical Engineering at the Fuzhou University. He graduated from Nanyang Technological University (NTU, Singapore) with a PhD in Materials science (2013), developing functional materials for environmental protection. After that, he did a postdoc at NTU, and worked on advanced functional materials for energy conversion and storage application. Before joined Fuzhou University in 2020, he joined in the Institute of Applied Physics and Materials Engineering (IAPME) at University of Macau as an assistant professor.

Publications

• Research   
  Enhancement of Oncolytic Activity of oHSV Expressing IL-12 and Anti PD-1 Antibody by Concurrent Administration of Exosomes Carrying CTLA-4 miRNA
  Author(s): Runbin Yan, Xusha Zhou, Xiaoqing Chen, Xianjie Liu, Yuxin Tang, Jie Ma, Lei Wang, Ziwen Liu, Borui Zhan, Hong Chen, Jiamei Wang, Weixuan Zou, Huinan Xu, Ruitao Lu, Dongyao Ni*, Bernard Roizman* and Grace G Zhou*
  
  Systemic administration of checkpoint inhibitors alone and especially concurrent with intratumoral administration of oncolytic herpesviruses (oHSV) has a major impact on cancer therapy marred by rare failures of healthy organs. Furthermore, tumors vary with respect to susceptibility to oncolytic effects of oHSV. Here we report the construction and properties of 3 families of oncolytic herpes simplex viruses expressing no immunomodulatory genes (T1 series), murine IL-12 (T2 series) or murine or human IL-12 and anti PD-1 antibody (T3 series). We report that insertion of the gene encoding PD-1 Ab significantly augmented the oncolytic activity of oHSV bereft of immunostimulatory genes (T1 series) or expressing IL-12 alone (T2 series). The T3 oHSV expressed IL-12, PD-1 Ab were restricted to the tumor bed whereas the induced IFN-γ accumulated to high levels both in tumor bed and in bl.. View More»
  DOI: 10.35248/2471-9552.19.5.154

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