ISSN: 2329-8901
Department of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, United States
Yuying Liu currently works at the Department of Pediatrics, McGovern Medical School, the University of Texas Health Science Center at Houston. Yuying does research in Pediatrics Gastroenterology, Mucosal Immunology, and Probiotics. Their current projects are 'The mechanism of Lactobacillus reuteri in regulating intestinal inflammation.', and "The effect of human breast milk on the function of probiotics"
Research
Human Breast Milk Promotes the Immunomodulatory Function of Probiotic Lactobacillus reuteri DSM 17938 in the Neonatal Rat Intestine
Author(s): Thomas K Hoang, Jasmin Freeborn, Ting Wang, Tu Mai, Baokun He, Sinyoung Park, Dat Q Tran, Stefan Roos, J Marc Rhoads and Yuying Liu*
Background and objective: Breast milk has many growth-promoting and immune-active components, including transforming growth factor-β, lactoferrin, lysozyme, immunoglobulin A, and prebiotics such as the human milk oligosaccharides. Treatment with Lactobacillus reuteri DSM 17938 (LR), a probiotic with immunomodulatory functions, significantly increases regulatory T cells (Tregs) in the intestinal mucosa of newborn suckling rats. In humans, treatment with LR of infants with colic reduces crying optimally if the infants are breast-fed. Therefore, we examined the effects of human breast milk (HBM) on LR-associated immune modulation.
Methods: Newborn rats were divided into 8 feeding groups, including dam-fed ± LR (106 CFU/kg bw/day, daily), formula-fed ± LR, formula with 20% (v/v) HBM-fed ± LR, and HBM.. View More»
DOI:
10.35248/2329-8901.19.7.210