Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Department of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
Research Article
Proteomic Analysis Provides Insights into the Molecular Regulatory Mechanism of Dengzhan Shengmai Capsule in a Rat Model of Vascular Dementia
Author(s): Jing Zhang, Wei Liu, Dongfeng Wei and Zhanjun Zhang*
Dengzhan Shengmai (DZSM) capsule is a compound Chinese medicine that is widely used in the clinic for the treatment of ischemic cerebrovascular diseases along with symptoms of dementia and forgetfulness. DZSM can improve the cognitive function and quality of life of patients with Vascular Dementia (VD), but little is known about the therapeutic mechanisms. In this study, we found that DZSM rescued spatial memory impairment in VD rats. We next employed an isobaric Tag for Relative and Absolute Quantitation (iTRAQ) based quantitative proteomic approach to uncover the specific proteins and biological pathways underlying the exacerbation of cognitive deficits observed in VD and to investigate the molecular mechanism of the effect of DZSM against VD. We discovered that the proteome was broadly changed in VD rat brains; among the 222 identified proteins with altered expression after VD mode.. View More»