ISSN: 2167-0250
+44 1300 500008
Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao 266021, China
Dr. Zhenhua Song is a researcher affiliated with the Department of Pharmacology at Qingdao University School of Pharmacy in Qingdao, China. His research primarily focuses on the intersection of pharmacology and neuroscience, with a particular interest in the molecular mechanisms underlying depression and the therapeutic potential of natural compounds. In a 2023 study, Dr. Song and his colleagues investigated the effects of krill oil on lipid metabolism and depression-like behaviors in mice. Their findings suggested that krill oil supplementation could ameliorate lipid metabolism imbalances and reduce depression-like behaviors induced by chronic unpredictable mild stress.
Mini Article
Understanding Testosterone Deficiency in Depression: Insights from Cholesterol Dynamics in Leydig Cells of CUMS Mice
Author(s): Jiaojiao Huang, Zhen Peng and Zhenhua Song*
This study mainly focused on the role of cholesterol dynamics in leydig cells to understanding testosterone deficiency in depression. Numerous studies have demonstrated a link between a higher risk of depression and low testosterone levels. Males with low testosterone frequently experience depressive symptoms and testosterone replacement therapy has been demonstrated to elevate mood in certain testosterone deficient individuals. Meanwhile, depression is frequently associated with hormonal imbalances, including testosterone deficiency. Recent research using chronic unexpected mild stress (CUMS) mice models has uncovered a significant connection between reduced testosterone levels and diminished cholesterol levels in Leydig cells, which are vital for testosterone production. This relationship highlights a significant intersection between mood disorders and metabolic processes... View More»
DOI:
10.35248/2167-0250.24.13.327
https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1180483/pdf?utm_source=chatgpt.com
https://daneshyari.com/article/preview/8537220.pdf?utm_source=chatgpt.com
https://loop.frontiersin.org/people/538944/overview?utm_source=chatgpt.com