Clinical Pediatrics: Open Access
Open Access
ISSN: 2572-0775
ISSN: 2572-0775
Department of Hepatology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
Research Article
Correlation Between Clinical Indicators and Liver Pathology in Children with Chronic Hepatitis B
Author(s): Chenyang Huang, Ying Lu, Ziwei Wang, Qiyu Jiang, Yi Dong, Lili Cao, Jianguo Yan, Zhiqiang Xu, Fuchuan Wang, Yinjie Gao, Junliang Fu, Min Zhang and Fu-Sheng Wang*
Background: Chronic Hepatitis B (CHB) in children presents a significant global health challenge, with liver
inflammation and fibrosis being critical concerns for disease progression and long-term outcomes.
Methods: This retrospective study analyzed 1629 pediatric CHB patients from the Fifth Medical Center of Chinese
PLA General Hospital, spanning from January 2000 to December 2021. Liver biopsies were performed to assess the
severity of liver inflammation and fibrosis. Key clinical Indicators, including age, Alanine Amino Transferase (ALT),
Aspartate Amino Transferase (AST), and Gamma-Glutamyl Transferase (GGT), were evaluated for their predictive
value in determining disease severity using restricted cubic spline regression models.
Results: Significant nonlinear associations were found between the clin.. View More»
DOI:
10.35248/2572-0775.24.09.282