Journal of Down Syndrome & Chromosome Abnormalities
Open Access
ISSN: 2472-1115
ISSN: 2472-1115
Department of Health Sciences, Centre National Hospitalier Universitaire-Hubert Koutoukou Maga, Cotonou, Benin
Case Report
Association of Down Syndrome, Sickle Cell Disease, and Leukemia: A Case Report
Author(s): Zohoun Lutece*
Trisomy 21 or Down syndrome (DS) is the most common chromosomal disorder in the world. Its prevalence is 1/800 live births worldwide. It results from a presence of three copies of chromosome 21 in the cells. Certain factors, such as maternal age over 35 years and exposure to radiation, may favor its occurrence. Sickle cell disease (SCD) is due to a gene mutation with autosomal recessive transmission, resulting in an amino acid substitution (glutamic acid is substituted by lysine) at position 6 on the β globin chain of hemoglobin. It is widespread in sub-Saharan Africa, the Mediterranean and Southeast Asia. Its prevalence is estimated to be around 300,000 births per year worldwide, with 2/3 occurring in Africa. This two genetic diseases increase morbidity and mortality in affected children, although current medical advances have increased their life expectancy in advanced countrie.. View More»