Journal of Proteomics & Bioinformatics
Open Access

9^th International Conference on Structural Biology

September 18-20, 2017 Zurich, Switzerland

Scientific Tracks Abstracts

• Nanoscale structure and dynamics of centromere nucleosomes

  Yuri L Lyubchenko

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• The structure of chromatin; single-molecule experiments on model fibers and real genes

  John van Noort

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• Deciphering and filming molecular recognition at the nano-scale with AFM

  Peter Hinterdorfer

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• High-speed optical tweezers for the study of protein-DNA interaction

  Marco Capitanio

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• Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

  Gijs Wuite

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• New applications of boxed molecular dynamics: Atomistic simulations of atomic force microscopy experiments and peptide cyclization

  Dmitrii V Shalashilin

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• Structural insights from aptamers with base modifications

  Nebojsa Janjic

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• HIV-1 integrase assembles multiple discrete intasomes that are active for DNA integration in vitro

  Robert Craigie

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• Allosteric control of transcription regulation by nuclear receptors: An integrative structural biology approach

  Dino Moras

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• Complex of malaria parasites and human proteins drive formation of cytoadherent assemblies at the surface of infected red blood cells

  John Vakonakis

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• Micro robotics enables non-contact, fully automated protein crystal harvesting

  David F Sargent

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• The native (Sulfur) SAD method in photon factory

  Toshiya Senda

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• Structural mechanisms of nucleosome recognition as revealed by methyl-TROSY

  Yawen Bai

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• New insights into pRN1 priming: Structural changes support specific DNA recognition and catalysis

  Julien Boudet, Jean-Christophe Devillier, Georg Lipps and Frederic H T Allain

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• A new protocol to investigate conformational population patterns in the enzymatic activity cycle of proteins using molecular dynamics and normal mode analysis

  Luis Paulo B Scott

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• Cryo-electron microscopy grid preparation from nanoliter-sized protein samples and single-cell extracts

  Thomas Braun, Stefan Arnold, Stefan Albiez, Andrej Bieri, Claudio Schmidli, Anastasia Syntychaki, Luca Rima, Nadia Opara, Shirley Muller, Kenneth N Goldie, Mohamed Chami and Henning Stahlberg

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• Structure based drug discovery on membrane protein targets: New developments and advancements

  Michael Hennig

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• Structure-based drug design of the EG5 inhibitor NVP-BQS481

  Dirksen E Bussiere

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• Does the dynamics of their transmembrane domain qualify bitopic membrane proteins as substrates for intramembrane proteolysis?

  Christina Scharnagl

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• The dynamics of a protein during its insertion into a membrane

  Andreas Kuhn, Dirk Spann and Maximilian Haase

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• Extract the thermodynamic and kinetic information from protein simulations using dimensionality reduction

  Shuanghong Huo and Gustaf H

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• Dynamics of knotted and entangled neurotoxic polypeptides

  Marek Cieplak

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• What docking studies tell us about the role of disordered protein fragments in macromolecular assembly

  Chantal Prevost

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• Structural analysis of vascular endothelial growth factor receptors reveals drug-targetable allosteric sites regulating angiogenesis

  Kurt Ballmer-Hofer, Sandra Markovic-Mueller, Edward Stuttfeld and Dragana Avramovic

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• A structure complex of a bacterial effort and an interacting protein: Insights into the transfer of virulence effector by pathogenic bacteria

  Jianyong Li, Han Qian and Binyu Zhao

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• Complex structure of mammalian cytochrome c–cytochrome c oxidase reveals a novel protein-protein interaction mode

  Kyoko Shinzawa-Itoh

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• Oxidative stress, methionine oxidation, and calmodulin structure and function

  Jeffrey L Urbauer

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• Molecular mechanism of SHP2 activation by CagA from Helicobacter pylori

  Miki Senda, Takeru Hayashi, Nobuhiro Suzuki, Lisa Nagase, Masanori Hatakeyama and Toshiya Senda

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• Integrative approaches to study the structure and motions of DNA sliding clamps

  Alfredo De Biasio

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• An atomistic view of microtubule stabilization by GTP

  Liliane Mouawad

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• Structure and function of a chloride pump rhodopsin from marine bacteria

  Hyun-Soo Cho

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• Construction of structural mimetics of the thyrotropin receptor intracellular domain

  Stanislav Engel

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• Structural basis of sodium/citrate symporter as a secondary transporter

  Mi Sun Jin, Ji Won Kim, Subin Kim, Haerim Lee, Songwon Kim and Jie-Oh Lee

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• Dynamics of biomolecules In Action studied with X-ray free electron lasers

  Petra Fromme

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• Protein machinery regulating the synaptic vesicle fusion

  Maria Bykhovskaia

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• Designer Biologics: BMP Chimeras and their clinical potential

  Senyon Teddy Choe

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• Structural mechanism of partial agonists and antagonists of PPARgamma for use as antidiabetics

  John B Bruning, Ted Kamenecka and Pat Griffin

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• How conformational dynamics descriptors may help in remodeling of allosteric regulation in proteins

  Luba Tchertanov

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• Study on the conformational transition between the alternative and collapsed form of prethrombin-2: Targeted molecular dynamics and free energy sampling

  Sangwook Wu, Hunjoo Myung

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• Structural and molecular dynamics analysis of the super secondary motifs from TIM barrel proteins: Implications for folding and engineering of foldable building blocks for the assembly of TIMS

  Ramakrishna Vadrevu

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• Solutions for studying protein complexes in structural biology and drug development

  Tobias Pfluger

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• Mechanisms underlying lipid-sensing by the nicotinic acetylcholine receptor in both normal and diseased states

  John E Baenziger

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• When structure leads to function: Protein complexes at the membrane in endocytosis

  Carsten Mim

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• Structural basis for the lipid-dependent gating of a Kv channel

  Qiu-Xing Jiang

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• How does domain motion contribute to transition-state stabilization? Combinatorial thermodynamic cycle analysis of conformational coupling during tryptophan activation

  Charles W Carter

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• Structure of human IgM in complex with the malaria protein PfEMP1

  Ulf Skoglund

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• Is nucleoid complexity hence cell diameter limited by the eclipse?

  Arieh Zaritsky

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• Inter-domain communication through intrinsically disordered region (IDR) revealed through the ensemble structure analysis

  Shin-ichi Tate

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• Solution NMR relaxation and μs molecular dynamics simulations of dynamic protein-protein and protein-membrane complexes

  Matthias Buck

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• Functional protein conformation networks probed by NMR nanorulers

  Beat Vogeli

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• On two ways to predict the protein folding process over a chaotic model

  Christophe Guyeux

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• Antibodies as research tools to find new chemical matter

  Marta Westwood

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• Structural genomics of integral membrane proteins - Past successes and future directions

  Brian Kloss

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• Geometrical principles of homeric β-barrels and β-helices: Applications to modelling amyloid protofilaments

  Steven Hayward

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• Exploring conformational equilibria of a heterodimeric ABC transporter by electron paramagnetic resonance

  Enrica Bordignon

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• Microscopic calculation of conformational thermodynamics in bio-macromolecular complexes

  Jaydeb Chakrabarti and Mahua Ghosh

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• Calcium, calmodulin and the plasma membrane calcium pump

  Joachim Krebs

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• Structural insights into cholesterol regulation of inwardly-rectifying K+ channels

  Irena Levitan

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• Structural aspects of cell signaling

  Carol A Heckman

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• Mechanical stability of talin rod controls traction force generation and cell migration

  Vesa P Hytonen, Rolle Rahikainen, Magdalena von Essen, Markus Schaefer, Lei Qi, Latifeh Azizi, Conor Kelly, Teemu O Ihalainen, Bernhard Wehrle-Haller4, Martin Bastmeyer and Cai Huang

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• Photoinduced electron transfer in cytochrome bc1: Kinetics of ubiquinone transfer from the Qo site to the Qi site, and evidence for communication between the monomers in the dimer

  Francis Millett

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• Mapping energy transfer channels in fucoxanthin-chlorophyll protein complex

  Leonas Valkunas

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• PIP2 modulation of KCNQ1 channels

  Jianmin Cui

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• LD motif interacting networks in cell-matrix adhesion

  Igor L Barsukov

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• Structural conformational changes report biased agonism: The case of galanin receptors

  Arfaxad Reyes Alcaraz

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• A biophysical and structural approach to investigate calcium sensor properties of plant calmodulinlike proteins

  Alessandra Astegno

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• Structural insights into the mechanism of how polyphenols suppress amyloid fibrillation

  He Jianwei

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• Type I BIR domain inhibitors in cancer therapy: Designing drugs to modulate the NF-dB pathway

  Federica Cossu

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• The NMR studies of the interaction between polysialic acid (polySA) and the PSTD peptide in ST8Sia IV polysialytranseferase

  Guo-Ping Zhou

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• Understanding differential selectivity of arrestins toward the phosphorylation state of G-proteincoupled receptors

  Ozge Sensoy

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• Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

  Stephen M Soisson

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• Conformational dynamics revealed by ensemble cryo-EM

  Andrei Korostelev

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• Structural basis for PTPN3 - p38gamma complex involved in colon cancer progression

  Tzu Ching Meng

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• Holliday junction resolvase GEN1 functions as a versatile DNA sensor and processor

  Christian Biertumpfel

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• Monitoring protein structural changes on a proteome-wide scale

  Paola Picotti

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• Slow domain reconfiguration causes power law kinetics in a two-state enzyme

  Hagen Hofmann, Iris Grossman Haham, Gabriel Rosenblum and Trishool Namani

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• Structural and dynamic studies of DENV and ZIKV proteases and its insight into inhibitor design

  CongBao Kang

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• Assembly mechanism of foreign dsDNA-sensing inflammasomes

  Jungsan Sohn

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• Functional divergence in protein families: A co-variation analysis

  Marie Chabbert

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• RNA-binding domain disorder modulates the RNA destabilizing activity in the TTP family of proteins

  Francesca Massi

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• Role of conformational equilibrium in molecular recognition and capsid assembly: The case of flavivirus capsid proteins

  Fabio C L Almeida

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• Integrative approaches for variant interpretation in coding regions

  Sushant Kumar

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• Generation of long acting therapies using glycosylated linkers

  Abdulrahman Alshehri, R.J.Ross and I.R.Wilkinson

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• Hydrogen bond interaction with trypanosomal adenosine kinase; ornithine decarboxylase and triose phosphate isomerase could not be involved in the antitrypanosomal activity of stigmasterol: An in silico study

  Aminu Mohammed and Mohammed Auwal Ibrahim

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• XFEL structures of the M2 proton channel of influenza A reveal pH-dependent water networks under room temperature conditions

  Jessica L Thomaston

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• Crystal structure of DNA-binding domain-CbnR with its promoter reveals the basis of the LysR-type transcriptional regulator recognition

  Maharani Pertiwi Koentjoro, Naruhiko Adachi, Miki Senda, Toshiya Senda and Naoto Ogawa

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• Delivery methods for free electron lasers: Direct protein crystallization on solid supports economizes sample consumption in serial femtosecond crystallography

  Nadia L Opara,, Isabelle Martiel, Stefan A Arnold, Thomas Braun, Henning Stahlberg and Celestino Padeste

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• The challenge of improve disease treatment with protein engineering. The contributions of X-ray crystallography

  Stephanie Bath de Morais and Tatiana A C B Souza

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