Transcriptomics: Open Access
Open Access
ISSN: 2329-8936
ISSN: 2329-8936
Brij B Singh
Professor, Department of Biochemistry & Molecular Biology
University of North Dakota, USA
"Brij Singh: Our research is directed towards, identification and regulation of the molecular mechanisms involved in Ca2+ signaling. Members of the TRPC and Orai superfamily have been suggested as Ca2+ channels and have been implicated in several diseases; however the physiological function(s) and their mechanism of regulation have not yet been established. Thus our studies are directed specifically towards characterization of TRPC and Orai proteins in neuronal and non neuronal cells, define the molecular mechanism involved in their regulation, identify the role of TRPC and Orai proteins in differential gene expression, and evaluate their role in diseases such as Parkinson’s, Alzheimer, Sjogren’s, Dariers disease and Cancer. Our research could eventually lead to the identification of molecular targets or could serve as markers for early diagnosis for these diseases. We use cutting edge molecular, biochemical, and physiological methods for this exciting research. Recently we have started experiments to identify the microRNAs and epigenetic regulations in these diseases. These targets genes/proteins are currently validated using proteomics and other biochemical approaches. In addition we are also interested in developing technology for early diagnosis of these diseases. "
"Brij Singh: Our research is directed towards, identification and regulation of the molecular mechanisms involved in Ca2+ signaling. Members of the TRPC and Orai superfamily have been suggested as Ca2+ channels and have been implicated in several diseases; however the physiological function(s) and their mechanism of regulation have not yet been established. Thus our studies are directed specifically towards characterization of TRPC and Orai proteins in neuronal and non neuronal cells, define the molecular mechanism involved in their regulation, identify the role of TRPC and Orai proteins in differential gene expression, and evaluate their role in diseases such as Parkinson’s, Alzheimer, Sjogren’s, Dariers disease and Cancer. Our research could eventually lead to the identification of molecular targets or could serve as markers for early diagnosis for these diseases. We use cutting edge molecular, biochemical, and physiological methods for this exciting research. Recently we have started experiments to identify the microRNAs and epigenetic regulations in these diseases. These targets genes/proteins are currently validated using proteomics and other biochemical approaches. In addition we are also interested in developing technology for early diagnosis of these diseases. "