Immunotherapy: Open Access
Open Access

Jean-Francois Fonteneau

Biography

Jean-François Fonteneau received the Ph.D. degree from Nantes University, France, in 1999. During his thesis training in the INSERM Laboratory of Pr Francine Jotereau, Nantes, France, he studied CD8+ T lymphocytes response against melanoma and how to induce such response. He then joined Dr Nina Bhardwaj’s group in Dr Ralph Steinman Laboratory as a Postdoctoral Fellow at Rockefeller University, New York, USA, from 1999 to 2003, where he studied dendritic cells (DC) biology, notably cross-presentation of viral and tumor antigens and interactions between virus, myeloid DC and plasmacytoid DC. In 2003, he returned to Pr Francine Jotereau Laboratory, INSERM U892, in Nantes to identify new melanoma epitopes recognized by patient’s CD8+ and CD4+ T cells. In 2009, He joined Dr Marc Gregoire's Laboratory, INSERM U892, Nantes, to study attenuated measles virus as an oncolytic virus for oncolytic immunotherapy of pleural mesothelioma to induce immunogenic cell death of tumor cells to initiate or increase the antitumor immune response.

Research Interest

Cancer immunotherapy
Oncolytic viruses
Measles virus
Immunogenic cell death
Antitumor immune response
Dendritic cells
T cells
Tumor antigen
Cross presentation