Journal of Pollution Effects & Control
Open Access
ISSN: 2375-4397
ISSN: 2375-4397
Kezhong Zhang
Assistant Professor, School of Medicine
Wayne State University, Detroit, Michigan, USA
Dr. Kezhong Zhang is Assistant Professor of Molecular Medicine & Genetics and of Immunology and Microbiology at the Wayne State University School of Medicine, Detroit, Michigan. He obtained his Ph.D from Fudan University and postdoctoral training from University of Michigan School of Medicine and Howard Hughes Medical Institute. He has been leading a research group at the Wayne State University, focusing on research in intracellular stress signaling pathways from the endoplasmic reticulum (ER) and mitochondria that modulate cell metabolism and inflammatory responses associated with metabolic disease and cancer. He characterized the roles of the ER stress sensor IRE1α in regulating B cell differentiation and function. He also revealed the molecular mechanisms and physiological roles of a novel liver-specific, stress-inducible transcription factor CREBH in acute phase response and hepatic lipid metabolism. More recently, research from Dr. Zhang’s group demonstrated that exposure to real-world ambient particulate matter in fine ranges induces non-alcoholic steatohepatisis (NASH) and impairs liver glucose metabolism. Dr. Zhang published more than 50 important scientific publications in high-profile journals, including Cell, Nature, Science, J. Clin. Invest., EMBO, and PNAS. His research programs were funded by National Institutes of Health (NIH), US Department of Defense (DOD), and American Heart Association (AHA).
Dr. Kezhong Zhang's research is focusing on intracellular stress signaling pathways from the endoplasmic reticulum (ER) and mitochondria that modulate cell metabolism and inflammatory responses associated with metabolic disease and cancer. He characterized the roles of the ER stress sensor IRE1α in regulating B cell differentiation and function. He also revealed the molecular mechanisms and physiological roles of a novel liver-specific, stress-inducible transcription factor CREBH in acute phase response and hepatic lipid metabolism.