Translational Medicine
Open Access

Matiullah Khan

Biography

Dr Khan is a Senior Research Scientist and an Assistant Professor of department of Medicine at National University of Singapore. He obtained his Ph.D. in Oncology from Graduate School of Medicine, University of Tokyo, Japan, in 1999. Later he worked at RIKEN, the premier research institute of Japan, as a Post-Doctoral Fellow and as a Research Scientist. In 2003, he joined the Oncology Research Institute (ORI) of National University of Singapore as an independent investigator. While working at National University of Singapore, he identified and characterized the protein misfolding pathway as an important oncogenic mechanism in some subtypes of AML, Lung and Liver Cancer. His current research is focused on therapeutic targeting of protein misfolding pathway in AML, Lung and Liver Cancer.

Research Interest

Role of N-CoR mediated transcriptional control in the regulation of growth and commitment of hematopoietic stem cells. Therapeutic targeting of N-CoR mediated epigenetic silencing in gastric cancer cells Role of misfolded conformation dependent loss (MCDL) of N-CoR in the malignant growth and transformation of tumor cells in AML, Lung and Liver cancer. Identification and characterization of molecular determinants of N-CoR misfolding pathway in AML, Lung and Liver cancer. Role of misfolded N-CoR in the activation of cytoprotective UPR (unfolded protein response) and autophagy Role of HVB-mediated N-CoR instability in hepatocellular carcinoma Identification and characterization of novel N-CoR conformation modifiers through high-throughput screening of small molecule library Previouse Appointments Research Awards Teaching Interest Research Interests.