Journal of Drug Metabolism & Toxicology
Open Access

Mohsen (Maxim) Sharifi

Biography

Education: Public health diploma, Master in Pharmacy, MPhil in Chemoinformatics and PhD in Molecular Modeling. Areas of responsibility include: - Current research project (2016) as postdoc fellow at FDA includes approaches for development and verification of novel SDAR modeling for activity mechanism discovery (including mutagenicity in amines, predictive mathematical modeling of ion channels (using RStudio and Matlab) from NMR chemical shifts as descriptor) and also included potential drug target identification using pharmacophore mapping approach. - Project in 2015 (FDA-Center for Tobacco Products): Application of Physiologically Based Pharmacokinetic (PBPK) models for nicotine. - Projects prior to 2015 involved using data mining techniques such as decision trees to develop Quantitative Structure-Activity Relationships for the prediction of biliary excretion of drugs. I am also investigating the significance of the transporters, P-gp and OATPs, in biliary excretion using ligand-enzyme docking and QSAR.

Research Interest

Main areas of interest/expertise: QSAR, Pharmacokinetics, Computational Chemistry, Molecular modeling and docking, In silico predictions of ADME/tox properties, Drug Design, Physico-chemical properties and drug metabolism, SDAR, Nicotine, PBPK.