Journal of Drug Metabolism & Toxicology
Open Access

Pritha Bhattacharjee

Biography

As a Ph. D. graduate student (2002-2008) from the CSIR-Indian Institute of Chemical Biology (CSIR-IICB), I have evaluated genetic changes in the population chronically exposed to arsenic through their drinking water. I acquired knowledge from epidemiological studies as well. During my post-doctoral work (2008-2011), I have extensively studied gene expression analysis from blood and tissue samples. Identified genetic variants from major pathways hampered by toxic insult and also conducted prospective studies to examine the arsenic-induced health issues in different exposure status. As a CSIR pool scientist (2011-2013), I have independently studied telomere dysfunction, senescence and epigenetic dysregulation in arsenic exposed population and how functional compensation of one gene occurs by its other family member. At present as a faculty in Dept of Environmental Science, I explore arsenic-induced epigenetic modifications (specially chromatin remodeling), study the trace metal profiles and their interaction, bioactive compounds and its amelioration capacity both at cell line and population level. At present, my team focus majorly on genetic-and epigenetic interactions, in cell line, mouse and human model system. We are also actively examining the effect of occupational toxicants and its impact on human health. We are working on several unorganized sectors and attempting to convert them towards green industry. Through technological interventions and sustainable solutions, our major objective remains to improve their occupational health.

Research Interest

Induced Toxicity and Carcinogenicity