Advancements in Genetic Engineering
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Shuji Ogino

Biography

Shuji Ogino, MD, PhD, MS (Epidemiology), is Associate Professor of Pathology at Harvard Medical School, Dana-Farber Cancer Institute and Brigham and Women′s Hospital, and Associate Professor (Epidemiology) at Harvard School of Public Health.  Dr. Ogino′s research focuses on molecular pathological epidemiology (MPE), epigenetics, and colorectal cancer and neoplasias.  Dr. Ogino established the interdisciplinary science "Molecular Pathological Epidemiology" (MPE) (Ogino et al. J Natl Cancer Inst 2010; Gut 2011; Nat Rev Clin Oncol 2011; Int J Epidemiol 2012; Am J Epidemiol 2012; etc.) as the first MPEist (MPE\\ist, MPE-ist).  The MPE field deciphers diseases at both the molecular and population levels and contributes to personalized medicine and personalized prevention.  Dr. Ogino created various novel paradigms, concepts and theorems, including the "Colorectal Continuum" theory (Yamauchi, Morikawa et al. Gut 2012; Yamauchi, Lochhead, et al. Gut 2012); "Unique Tumor Principle" (Ogino et al. Expert Rev Mol Diagn 2012; Int J Epidemiol 2012); and "GWAS-MPE Approach" for the post-GWAS (genome-wide association study) era (Ogino et al. Gut 2011).  Analogous to systems biology, MPE takes a holistic approach to incorporate diverse intersecting pathways and themes (such as epigenetics, genomics, energetics, inflammation, immunity, microbiome, microbiota, etc.) into integrated analysis of etiologies, evolution and progression of cancers as well as all other human diseases.  Dr. Ogino initiated the “MPE Method Working Group (MMWG)” and the “STROBE-MPE Initiative” in order to standardize methods in MPE research worldwide.  Dr. Ogino has published 128 original papers (as of July 2012; 75% of which he is the first or last author) in a variety of high-profile journals (including Nature, Nat Genet, NEJM, JAMA, J Clin Oncol, J Natl Cancer Inst, Genome Res, Gastroenterology, Gut, etc.).  Dr. Ogino′s work has been quoted over 5000 times in the past 5 years (since 2007).  Dr. Ogino has served in NIH Study Sections, and for other grant agencies.  Dr. Ogino conducted peer review for 80 journals (including NEJM, Nature series, Lancet, JAMA, etc) and has been an editorial board member for over 15 journals.  Dr. Ogino has served as a member of numerous national and international committees in molecular medicine, pathology and cancer societies (including AMP, CAP, USCAP, NCCN, ACS, CLSI, etc.).  Dr. Ogino received his MD and PhD from the University of Tokyo, and MS degree (in Epidemiology) from the Harvard School of Public Health.  As a result of his unique and pioneering work in establishing and developing MPE, Dr. Ogino received the prestigious Ramzi Cotran Young Investigator Award in 2011 from United States and Canadian Academy of Pathology (USCAP).

Research Interest

Molecular Pathologic Epidemiology and Epigenetics of Colorectal Neoplasia