Mycobacterial Diseases
Open Access

Uma S. Gautam

Biography

After finishing my Master’s degree in Biotechnology from the University of Allahabad, India and a PhD in Life Sciences from Devi Ahilya University, India in 2007, I studied the molecular mechanisms behind DosR signaling in M. tuberculosis in response to hypoxia at All India Institute of Medical Sciences as Scientist Pool Officer. Then, I joined the Division of Bacteriology and Parasitology at the Tulane National Primate Research Centre and interested to study the infection phenotype of various stress response mutants of M. tuberculosis in rhesus macaque and C3HeB/FeJ mice model of tuberculosis. I have contributed to the understanding of non-coding RNAs (small RNAs) that are expressed in M. tuberculosis upon exposure to diamide and hypoxia and their role in tuberculosis disease. I am currently investigating the role of IDO in TB pathogenesis in rhesus macaque model, and also interested to identify the regulatory proteins/ molecules involved in TB pathogenesis, using RNA sequencing with the goal to translate these findings into better therapies for tuberculosis disease. I have been involved in my investigative career for approximately 10 years, and serving as a reviewer of Journal of Bacteriology, Gene, PLoS One, European Journal of Inflammation, International Journal of Immunopathology and Pharmacology, Future microbiology. I am an early career Scientist Awardee of Collaboration of Tuberculosis and vaccine Discovery - Bill and Melinda Gates Foundation.

Research Interest

I am currently investigating the role of IDO in TB pathogenesis in rhesus macaque model, and also interested to identify the regulatory proteins/ molecules involved in TB pathogenesis, using RNA sequencing with the goal to translate these findings into better therapies for tuberculosis disease.