Journal of Developing Drugs
Open Access

Zhe Sheng Chan

Biography

Dr. Zhe-Sheng (Jason) Chen, M.D., PhD, is currently a Professor and a Director of Cancer Pharmacology Laboratory at College of Pharmacy and Health Sciences, St. John’s University. He joined St. John’s University in 2004 as an assistant professor. Since 2008, he established several research projects to study ABC transporters and multidrug resistance (MDR) as well as reversal of MDR in both in vitro and in vivo tumor models. During past 8 years, his laboratory has been well funded by NIH and Companies. He published more than 100 peer-reviewed research articles and 2 book chapters. He carried out his postdoctoral training at Fox Chase Cancer Center (Philadelphia, USA, 2000-2004) and Kagoshima University Faculty of Medicine (Japan, 1998-2000). He received his Ph.D. degree from Kagoshima University Faculty of Medicine (Japan, 1994-1998), Master degree from Sun Yat-Sen University School of Public Health (China, 1985-1988) and M.D. from Guangdong Medical and Pharmaceutical College (China, 1980-1985).

Research Interest

Physiology, Pharmacology and Pathology of ATP-binding cassette (ABC) transporters; Cellular and Molecular Mechanisms of multidrug resistance. Chen laboratory is interested in the molecular and cellular pharmacology of anticancer drugs, such as drug resistance mechanisms and reversal of resistance study and new drug development. A promise of our research program is that progress in the chemotherapy of cancer will depend on rational combination of agents that reduce the function of plasma membrane transporters such as P-gp, ABCG2 and MRPs, and to enhance the actions of cytotoxic drugs. In collaboration with many researchers in USA, China, Japan, Canada, Australia and Egypt, studies in Chen’s laboratory focus on screening and identifying new inhibitors of ABC transporters by in vitro membrane vesicles transport assay system and cell based assay systems. Another research direction is to study the role of ABC transporters family on the detoxification of chemicals (including carcinogens and mutagens) using knock out mouse models.