Journal of Women's Health Care

Journal of Women's Health Care
Open Access

ISSN: 2167-0420

Commentary - (2022)Volume 11, Issue 9

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A comprehensive exploration of breast ductal carcinoma and its prognostic implications

Esther Sauria*
 
*Correspondence: Esther Sauria, Department of Medical Oncology, Vall d’Hebron Hospital, Spain, Email:

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Abstract

The occurrence of ductal carcinoma in situ (DCIS) as an early type of neoplasia has increased since the implementation of breast screening programmes. Despite the good prognosis, 20%-50% of DCIS patients will develop invasive ductal carcinoma (IDC) if not treated. It is critical to look for promising biomarkers for predicting the prognosis of DCIS. In this study, the Gene Expression Omnibus (GEO) database was used to investigate the expression of genes that differed between DCIS and normal tissue. To characterise the biological role and intrinsic process pathway, enrichment analysis was used. The hub genes were classified using the Cancer Genome Atlas Breast Cancer Dataset, and the results were confirmed using the Cytoscape plugins CytoHubba and MCODE. The core gene signature's prognostic ability was determined using time-dependent receiver operating characteristic (ROC), Kaplan-Meier survival curve, Oncomine databases, and UALCAN databases. Furthermore, the prognostic value of core genes was demonstrated in proliferation assays. In the current study, we discovered 217 common differentially expressed genes (DEGs), with 101 upregulated and 138 downregulated genes. The PPI network was used to obtain the top genes (protein–protein interaction).

Keywords

Breast cancer, Microbiome, Microbiota therapy, Microbiome diversity.

Conclusion

According to the literature, the majority of patients (87%) were treated with mastectomy and axillary nodal evaluation, and the majority of them (73%) received locoregional radiotherapy after surgery. Only 8.7% of the patients had received adjuvant therapy, which typically included ovarian ablation (4.5%). There was no significant difference in treatment between patients with invasive ductal carcinoma and those with invasive lobular carcinoma. Invasive or in situ lobular carcinoma is thought to increase the risk of bilateral disease. Several studies have been conducted to assess the prognosis of patients with bilateral carcinoma.

References

  1. Toikkanen S, Pylkkanen L, Joensuu H. Invasive lobular carcinoma of the breast has better short-and long-term survival than invasive ductal carcinoma. BJC. 1997;76(9):1234-1240.

    2. Indexed at, Google Scholar, Cross Ref

  2. Kijima Y, Owaki T, Yoshinaka H, Aikou T. Synchronous bilateral breast cancer with Paget's disease and invasive ductal carcinoma: report of a case. Surg Today. 2003;33(8):606-608.

    3. Indexed at, Google Scholar, Cross Ref

  3. Agha RA, Franchi T, Sohrabi C, Mathew G, Kerwan A, Thoma A, et al. The SCARE 2020 guideline: updating consensus surgical CAse REport (SCARE) guidelines. IJS. 2020;84:226-230.

    4. Indexed at, Google Scholar, Cross Ref

  4. Purkayastha A, Sharma N, Lohia N. A rare case of triple negative synchronous bilateral invasive ductal carcinoma of breast. AMHS. 2016;4(1):67.

    5. Indexed at, Google Scholar, Cross Ref

  5. Abboud M, Nitsch P, Weidman JM, Schwartz MR, Desai SS, Lim S, et al. Patients with bilateral breast ductal carcinoma in situ treated with accelerated partial breast irradiation—initial experience. J Radiat Oncol. 2014;3(3):293-298.

    6. Indexed at, Google Scholar, Cross Ref

  6. Vuoto HD, García AM, Candás GB, Zimmermann AG, Uriburu JL, Isetta JA, et al. Bilateral breast carcinoma: clinical characteristics and its impact on survival. J Breast. 2010;16(6):625-632.

    7. Indexed at, Google Scholar, Cross Ref

Author Info

Esther Sauria*
 
Department of Medical Oncology, Vall d’Hebron Hospital, Barcelona, Spain
 

Citation: Sauria E (2022) A Comprehensive Exploration of Breast Ductal Carcinoma and its Prognostic Implications. J Women's Health Care 11(9):602.

Received: 27-Aug-2022, Manuscript No. JWH-22-19762; Editor assigned: 01-Sep-2022, Pre QC No. JWH-22-19762; Reviewed: 14-Sep-2022, QC No. JWH-22-19762; Revised: 19-Sep-2022, Manuscript No. JWH-22-19762; Published: 26-Sep-2022 , DOI: 10.35248/2167-0420.22.11.602

Copyright: ©2022 Sauria E, et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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