Journal of Applied Pharmacy
Open Access

A Note on Broad Spectrum of Posaconazole against Fungal Infections

Joseph Warner^{* *}Correspondence: Dr. Joseph Warner, Department of Medicine, The Royal Bournemouth Hospital, Castle Lane East, Bournemouth, BH7 7DW, UK, Tel: +44 (0)300 019 6175, Email:

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About the Study

Posaconazole is a triazole agent with a potent and broad antifungal in vitro against a range of different Candida species, Aspergillus species, Cryptococcus neoformans, the zygomycetes, and other filamentous fungi. Fungal pathogens, including Aspergillus spp. and Candida spp. are structurally related to itraconazole and inhibits lanosterol 14α-demethylase (CYP51), blocking the compound of ergosterol behaving in disabled cell membrane stability and accumulation of precursors leading to fungistatic or fungicidal paraphernalia.

Posaconazole (Noxafil, Schering Corporation, Kenilworth, NJ) was approved by the Food and Drug Administration for use as prophylaxis against invasive Aspergillus and Candida infections in immunocompromised case. Posaconazole differs in structure from the compact triazoles fluconazole and voriconazole in part by virtue of its extended side chain, held in common with itraconazole. Posaconazole differs from including over the presence of a furan ring and replacement of chlorine with fluorine. The extended side chains of posaconazole and itraconazole deliver added points of contact with the azole target, CYP51 (16). CYP51 is an integral membrane protein that functions as a 14-a-demethylase in the admixture pathway of the critical sterol of the fungal cell membrane, ergosterol. Inhibition of this enzyme results in abated membrane ergosterol content and accumulation of envenomed methylated brokers, with attendant derangement of fungal cell membrane function, growth inhibition.

Cases which are immunocompromised are at the upmost drawback of developing fungal infections; although ill cases in the hellacious care unit are also at pitfall Infections caused by Candida species are now more ordinarily seen in cases in the hellacious care unit than in those who are immunocompromised.

Fungal infections remain an important cause of morbidity and mortality in mended.

Invasive Fungal Disease (IFD) is associated with substantial morbidity and mortality Infections with Candida spp. are most often observed in hematology-oncology and surgical patients. Among solid organ transplant patients, lung transplant recipients are particularly at risk for IA.

Posaconazole is presently approved only for use as prophylaxis against IFIs in immunocompromised cases. However, countless case reports have valued the productiveness of posaconazole for the treatment of oropharyngeal candidiasis and refractory fungal infections.

The medicinal of posaconazole for prophylaxis of IFIs in immunocompromised cases is 200 mg three times daily. The medicinal of posaconazole for the treatment of fungal infections is 800 mg daily given in two or four divided medicinal. Each medicinal of posaconazole should be given with a full mess or liquid nutrient supplement to enhance absorption. However, unneeded antifungals should be considered, if a case cannot tolerate feedings.

Data from clinical trials indicate that posaconazole is well allowed, yea with long-term administration. The most ordinarily reported adverse events were fever, diarrhea, nausea, gagging, and headache. Other notable adverse events included hypokalemia, rash, thrombocytopenia, and abdominal pain. Other rare serious adverse events seen with posaconazole antidote include hemolytic uremic pattern, thrombotic thrombocytopenic purpura, pulmonary embolus, adrenal insufficiency, and antipathetic or hypersensitiveness answers. Elongation of the QT interval may be seen with posaconazole as well as with the other triazole antifungals.