Although foremost potent and recently developed antimicrobial medicine are offered throughout the globe, in developing countries their use is confined to people who are flush enough to afford them. In tertiary referral hospitals like the Kenyatta National Hospital in Nairobi, Kenya, the primary line antimicrobial medicine used are Polycillin, Chloromycetin, Co-amoxiclav, Co-trimoxazole, Ethril, Gentamicin, Penicillin, and bactericide [1]. Amikacin, Cefuroxime, antibiotic, and antibacterial are used as second line agents. In district hospitals solely the primary line agents are offered, however typically not even these are offered.

In many developing countries the utilization of antimicrobial drugs for treating of humans and animals is not regulated; antibiotics are regularly purchased in pharmacies in under developed countries as over the counter drugs [2]. At intervals the Rajbari district of People's Republic of Bangladesh, a survey of rural medical practitioners (barefoot doctors) with a minimum of 11 years’ experience showed that an average of 380 patients per month are prescribed with antibiotics per hour on the basis of symptoms alone. In one month 14, 950 patients were prescribed with antibiotics—a total of 2915 hundred doses. Exclusively 1095 hundred doses had been distributed by pharmacies, and an extra 100 doses had been distributed as over the counter drugs [3].

Thus there is widespread and uncontrolled use of antibiotics, and patients generally do not take a full course of treatment if they are not cost effective. Another drawback in developing countries is the standard and potency of antimicrobial medication [4]. When the course of medication is discontinued the microbes become resistant to that particular antibiotic (for eg: UTI infections if the due course is discontinued it leads to reoccurrence of UTI).

Diarrheal malady might be a significant reason for morbidity and mortality in developing countries. Although retroviral infections are the reason for the malady in infants. As a result of laboratory facilities are not wide on the market most of the patients are treated by trial and error with antibiotics. Infection with eubacteria species and eubacterium cholerae frequently causes epidemics [5]. Over the years eubacteria species have shown an honest propensity to develop resistance to antibiotics. As an example, in 1996 in Matlab and national capital, Bangladesh, over ninety fifth of eubacteria dysenteriae isolates were proof against Principen, Co-trimoxazole, and bactericide, and 14-40% were given with Mecillinam [6]. This was associate degree outsized increase over the half resistant isolates notable in 1991, before the drug was wide on the market. Throughout infectious disease epidemics the organism has the flexibleness to develop increasing resistance, typically by acquisition of plasmids. In land throughout a infectious disease epidemic in 1985-6 there was a case death rate of 13 as a results of the initially sensitive V cholerae quickly noninheritable body encoded resistance to Principen, Kanamycin, antibiotic, sulphonamides, and bactericide [7].

Sexually transmitted infections are the most frequently occurring infections worldwide, it has been estimated that among adults with an age group of 15-49 years there are 332 million cases of sexually transmitted diseases worldwide [8]. These STD’s were reported for 365 days of the full style of cases, contagious disease for eighty seven percent, chlamydiosis for twenty sixty six percent; over 66% of these infections occurred in people from developing countries. Microorganism have shown potentcy in developing resistance to antimicrobial drugs in conmibination with drugs like Sulphonamides, Penicillins, Fluoroquinolones like Ofloxacin, Norfloxacin, Levofloxacin, Ciprofloxacin and Nalidixic acid have evidenced extraordinarily effective in treating contagious disease but once widespread and sometimes inappropriate use Fluoroquinolone resistant N. gonorrhoeae has emerged [9]. In some areas this leaves third generation cephalosporins, like Cefuroxime, Cephamycin as a result of the entirely predictably effective antibiotic treatment for contagious disease.

Bacterial agents potency against treatment with antibiotics are frequently reoccurring in hospitals in developing countries. Most resistant bacteria such as Mycobacterium. Tuberculosis causing TB, S Pneumonia, S Typhi ) and hospital innate organism (Klebsiella pneumoniae , enterobacteria , and genus Pseudomonas aeruginosa ) do cause issues [10-13]. Antibiotic medicine like antibiotic resistant S aureus (MRSA) is apace growing within the developing world what is more as African nation, Sri Lanka. The foremost vital factors related to its widespread were found to be poor hospital hygiene, overcrowding, lack of resources for infection management, and absence of trained personnel within the predominant infections in hospital [14,15].

Antimicrobial medication plays an important resource that has to be preserved for future use. In developing countries laboratory diagnostic facilities are very poor and this has crystal rectifier to the introduction of empiric, and drawback adjusted management ways that for the administration of antimicrobial medication. Inevitably this leads to overtreatment.

For the long run the priority need to be given to the laboratory infrastructure in developing countries. This may not entirely profit the individual patients however supply early warnings for the emergence of resistant isolates. This might be valuable however the price need to be balanced against the chance of the event of untreatable infections in vulnerable populations [16,17]. Finally, there need to even be larger regulation of the intake of antibiotics in developing countries; this might be among ways that to point out the ultimate public, doctors, and veterinarians on the acceptable use of antibiotics.