Journal of Yoga & Physical Therapy

Journal of Yoga & Physical Therapy
Open Access

ISSN: 2157-7595

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Review Article - (2015) Volume 5, Issue 4

An Overview of Yoga Research for Health and Well-Being

Erik J Groessll*, Deepak Chopra and Paul J Mills
Department of Family Medicine and Public Health, University of California San Diego, USA, E-mail: dchopra@iiserb.ac.in
*Corresponding Author: Erik J Groessll, Department of Family Medicine and Public Health, University of California San Diego, USA, Tel: (858) 642-6347, Fax: (858) 552-4321 Email:

Abstract

The amount and quality of research on the impact of yoga for improving health and treating medical conditions has increased dramatically in the past decade. It has also become quite specialized, with most reviews of yoga research focusing only a single disease or population. Our objective was to review the state of research more broadly, providing examples of and references for notable yoga research across many different research modalities, diseases, and populations.

Introduction

Yoga is part of mainstream culture today, with major medical centers, community healthcare centers, and neighborhood yoga studios offering yoga as a mind-body practice to support health and healing. In the US, over 20 million individuals now practice yoga, with studios found in nearly every state. Although yoga has existed in various forms for around 2500 years, the phenomenon of “yoga for health” is a characteristic of more modern yoga [1].

While scientific research on the health effects of yoga postures has been conducted and published for many years this line of scientific inquiry has grown tremendously only in the last 10-20 years, especially in terms of more rigorous randomized, controlled trials (RCT) [2,3] A search on the US National Library of Medicine’s biomedical database PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) now yields approximately 3,150 scientific publications on yoga. In addition to RCTs of the health benefits of yoga, there are many other important avenues of yoga research such as epidemiological research that helps researchers to understand the characteristics of people who practice yoga, methodological and measurement research to improve the quality of yoga research, and qualitative yoga research with narratives that directly carry the voices of those who teach and practice yoga [4-9]. There has also been considerable research done on the more general physical effects of yoga practice [10,11]. With this large upsurge in research documenting the therapeutic effects of yoga, efforts have been underway to understand the mechanisms of these health benefits, including research on inflammation and the autonomic nervous system [12-20].

In addition to yoga research being conducted on adults, there is increasing interest in the benefits of yoga on a more complete span of individuals - including school age children, adolescents, expectant mothers, and the elderly [21-30]. Yoga research is quickly being extended to other populations as well, including people in the workplace, among athletes, and a strong new interest in yoga research among active duty military and veterans with pain conditions, combat stress and Post Traumatic Stress Disorder (PTSD) [31-39].

With the emergence of higher quality yoga research, there is evidence that yoga has sizable and replicable effects for many health conditions. Although health is viewed as holistic in yogic traditions and aspects of health are clearly intertwined, research often targets specific areas such as physical health, mental health, and/or spiritual well-being. Some conditions that have been well studied include depression, stress and anxiety, irritable bowel syndrome, HIV, heart conditions, cancer, and chronic low back pain (CLBP) [40-43]. With CLBP, for example, a recent review documented consistent findings that yoga can improve function and decrease pain in people with CLBP [44,45]. Additionally yoga practice among people with CLBP reduces depression and pain medication use and improves quality of life [46-48].

There have been studies examining the potential benefits of yoga for cancer survivors, with the majority of research focusing on alleviating symptoms of radiation or chemotherapy, such as fatigue. A recent review concluded that yoga improves quality of life and psychosocial outcomes including depression in cancer survivors, but evidence is limited for supporting improvements in fatigue or sleep [49,50].

Considerable research has also been conducted examining the effects of yoga on cardiovascular risk factors, including a recent review concluding that yoga is a promising method for reducing high blood pressure (hypertension). Other reviews too report a variety of beneficial effects of yoga for cardiovascular diseases more broadly [51]. For asthma, the breathing component of yoga has been linked to improvements in lung function, but has not proven to be better than standard breathing exercises for those specific outcomes [52-54].

While there have been studies conducted on the effects of yoga for other health conditions, these are more pilot and/or small research studies and the results are considered more preliminary at best, or inconclusive. This is not surprising, given it is only recently that adequate research funding has been available to conduct the larger, more rigorous scientific studies.

Clearly, in cases where yoga does not offer significant relief from physical disease, it can still offer some measure of relief from suffering. In this sense, yoga can provide a different way of looking at pain and suffering, which in itself can potentially alleviate some suffering. The basic realization that “I” am not my body, or my thoughts, or my sensations of pain, is itself healing or liberative from a certain kind of existential suffering.

Along these lines, yoga has also been increasingly studied as a treatment or adjunctive treatment for a variety of mental health disorders. Many studies have found that yoga can reduce symptoms of stress or generalized anxiety, schizophrenia, depression, PTSD, and substance use, but these studies vary in size, quality, and methodology [41,42,55-61]. A recent systematic review of 25 randomized control studies examined the effects of yoga on sympathetic nervous system and hypothalamic pituitary adrenal axis regulation measures, as well as structural and functional brain measures in regions involved in stress and mood regulation. The review suggested that yoga practice leads to better regulation of autonomic nervous system and a decrease in depressive and anxious symptoms in a range of populations [62].

A recent report and comprehensive review of evidence and guidelines by the Canadian Agency for Drugs and Technologies in Health (CADTH) analyzed the quality of the evidence for yoga as a treatment for a few specific mental health disorders and provided references to studies and guidelines for each of these mental health areas [63]. To summarize the conclusions of this evidence-review, the report found evidence supporting yoga as a treatment or adjunctive treatment for depression. However, depending the type and severity of depression, yoga may be recommended as a second-line or thirdline treatment after medication and psychotherapeutics. In more severe depression where suicide is a major risk, yoga is best viewed as adjunctive to other treatments.

The report found that the methodology and quality of studies on yoga and generalized anxiety disorder (GAD) vary considerably and evidence is considered preliminary. Studies tend to be small pilot projects and many different measures of stress and/or anxiety were used. At least one randomized pilot study provided preliminary evidence that yoga improved GAD symptoms [55]. Other anxiety disorders were not reviewed but two previous review studies summarize preliminary evidence in other disorders or stress/anxiety symptoms more generally [64,65].

The CADTH report judged the evidence of yoga for treating PTSD as unclear, although there are some promising pilot studies that have found beneficial effects in recent years.[58,59] Most studies have focused on survivors of natural disasters or on women with a history of domestic-abuse or sexual trauma, and only two of over ten studies have focused on military or combat-related trauma, with only the single 2014 study presenting quantitative results [66,67].

Finally, the CADTH review concluded that the studies showing impact of yoga for reducing alcohol or drug use are of low quality. Thus, the benefits of yoga for substance use and addictions are an area that appears promising, but much more research is needed.

In addition to the detailed CADTH review on yoga for specific mental health disorders, the effects of yoga on psychological symptoms is often studied in other diseases where they co-occur or in at-risk populations[38,68-70]. While it is difficult to succinctly summarize this diverse literature, most studies report beneficial effects of yoga on mental health and well-being, but most are smaller pilot studies.

With few exceptions among all of the research that has been conducted, findings indicate that yoga rarely has harmful effects and is well received by participants. There may be certain poses or types of yoga that are not good for certain health conditions, and good research is done in collaboration with clinical experts and certified yoga instructors who can guide the choice of the style of yoga that will produce the most benefit. Like other exercise activity, the risks of injury from improperly performing yoga postures vary depending on how, where, and with whom the yoga is practiced. The initial practice of yoga under the direction of experienced yoga instructors is thus recommended, as is following a program that has been modified specifically for people with the afflicting health condition. For optimal safety, individuals with specific health concerns should consult their physician before starting a yoga program. While there have been media stories alerting people to the dangers of yoga, data from most research studies reveal very few serious adverse events [36]. For example, in RCT studies of adults with CLBP taught by experienced yoga instructors, three serious adverse events were reported among 308 persons and each was related to herniated discs, and at least one of these was found to be unrelated to yoga practice. Disc problems are common in CLBP in the absence of yoga practice, and thus may have occurred just as readily with inactivity or other activity [44,45].

It is important to note that the original purpose of yoga – to increase one’s spiritual well-being or connection with the divine - has typically been a neglected area for researchers. The popularity of yoga as an exercise that is being done in health clubs has probably led to some de-emphasis of spirituality. We have seen a sort of translation of the spiritual system of yoga into a form of practice acceptable in a secular context, and an integral feature of yoga is that it adapts to each unique historical era and cultural context [71]. While it is true that some people may be more likely to refuse to try yoga if spirituality is emphasized, it may be possible for the spiritual aspects of yoga to be woven in gently as a feature of yoga practice while emphasizing other physical and mental health benefits as described in this article [72]. To this effect, one study found that the reasons for starting versus continuing yoga changes over time, becoming mostly a spiritual reason after a period of regular practice. Many studies report that the practice of yoga enhances one’s spiritual well-being [73-80].

References

  1. Alter JS (2004) Yoga in Modern India: The Body between Science and Philosophy. Princeton University Press.
  2. Vakil RJ (1950) Remarkable feat of endurance by a yogi priest.Lancet 2: 871.
  3. Elwy AR, Groessl EJ, Eisen SV, Riley KE, Maiya M, et al. (2014) A systematic scoping review of yoga intervention components and study quality.Am J Prev Med 47: 220-232.
  4. Barnes PM, Bloom B, Nahin RL (2008) Complementary and alternative medicine use among adults and children: United States, 2007.Natl Health Stat Report : 1-23.
  5. Birdee GS, Legedza AT, Saper RB, Bertisch SM, Eisenberg DM, et al. (2008) Characteristics of yoga users: results of a national survey.J Gen Intern Med 23: 1653-1658.
  6. Cerrada CJ, Weinberg J, Sherman KJ, Saper RB (2014) Inter-method reliability of paper surveys and computer assisted telephone interviews in a randomized controlled trial of yoga for low back pain. BMC Res Notes 7: 227.
  7. Park CL, Groessl E, Maiya M, Sarkin A, Eisen SV, et al. (2014) Comparison groups in yoga research: a systematic review and critical evaluation of the literature.Complement Ther Med 22: 920-929.
  8. Saper RB, Boah AR, Keosaian J, CerradaC, Weinberg J, et al. (2013) Comparing Once- versus Twice-Weekly Yoga Classes for Chronic Low Back Pain in Predominantly Low Income Minorities: A Randomized Dosing Trial. Evid Based Complement Alternat Med 658030.
  9. Sherman KJ (2012) Guidelines for developing yoga interventions for randomized trials.Evid Based Complement Alternat Med 2012: 143271.
  10. Patel NS, Akkihebbalu SE, Espinoza,Chiodo LK (2011) Perceptions of community based yoga intervention for older adults. Activities, Adaptation Aging 151-163.
  11. Conboy LA, Noggle JJ, Frey JL, Kudesia RS, Khalsa SB (2013) Qualitative evaluation of a high school yoga program: feasibility and perceived benefits.Explore (NY) 9: 171-180.
  12. Telles S, Desiraju T (1991) Oxygen consumption during pranayamic type of very slow-rate breathing.Indian J Med Res 94: 357-363.
  13. Telles S, Desiraju T (1992) Heart rate and respiratory changes accompanying yogic conditions of single thought and thoughtless states.Indian J PhysiolPharmacol 36: 293-294.
  14. Telles S, Desiraju T (1993) Autonomic changes in Brahmakumaris Raja yoga meditation.Int J Psychophysiol 15: 147-152.
  15. Kiecolt-Glaser JK, Christian L, Preston H, Houts CR, Malarkey WB, et al. (2010) Stress, inflammation, and yoga practice.Psychosom Med 72: 113-121.
  16. Kiecolt-Glaser JK, Christian LM, Andridge R, Hwang BS, Malarkey WB, et al. (2012) Adiponectin, leptin, and yoga practice.PhysiolBehav 107: 809-813.
  17. Pullen PR, Nagamia SH, Mehta PK, Thompson WR, Benardot D, et al. (2008) Effects of yoga on inflammation and exercise capacity in patients with chronic heart failure.J Card Fail 14: 407-413.
  18. Pullen PR, Thompson WR, Benardot D, Brandon LJ, Mehta PK, et al. (2010) Benefits of yoga for African American heart failure patients.Med Sci Sports Exerc 42: 651-657.
  19. Agte VV, Jahagirdar MU, Tarwadi KV (2011) The effects of SudarshanKriya Yoga on some physiological and biochemical parameters in mild hypertensive patients.Indian J PhysiolPharmacol 55: 183-187.
  20. Yoshihara K, Hiramoto T, Oka T, Kubo C, Sudo N (2014) Effect of 12 weeks of yoga training on the somatization, psychological symptoms, and stress-related biomarkers of healthy women.Biopsychosoc Med 8: 1.
  21. Birdee GS, Yeh GY, Wayne PM, Phillips RS, Davis RB, et al. (2009) Clinical applications of yoga for the pediatric population: a systematic review.AcadPediatr 9: 212-220.
  22. Hunt K, Ernst E (2011) The evidence-base for complementary medicine in children: A critical overview of systematic reviews.Arch Dis Child 96: 769-776.
  23. Khalsa SB, Butzer B, Shorter SM, Reinhardt KM, Cope S (2013) Yoga reduces performance anxiety in adolescent musicians.AlternTher Health Med 19: 34-45.
  24. Khalsa SB, Hickey-Schultz L, Cohen D, Steiner N,Cope S (2011) Evaluation of the Mental Health Benefits of Yoga in a Secondary School: A Preliminary Randomized Controlled Trial. J Behav Health Serv Res 39: 80-90.
  25. Kuttner L, Chambers CT, Hardial J, Israel DM, Jacobson K, et al. (2006) A randomized trial of yoga for adolescents with irritable bowel syndrome.Pain Res Manag 11: 217-223.
  26. Mandanmohan, Jatiya L, Udupa K, Bhavanani AB (2003) Effect of yoga training on handgrip, respiratory pressures and pulmonary function.Indian J PhysiolPharmacol 47: 387-392.
  27. Babbar S, Parks-Savage AC, Chauhan SP (2012) Yoga during pregnancy: a review.Am J Perinatol 29: 459-464.
  28. Groessl EJ,Schmalzl L,Mazzi M,Iszak F (2013) Yoga for Low-Income Older Adults: Silver Age Yoga. J Yoga PhysTher.
  29. Patel NK, Newstead AH, Ferrer RL (2012) The effects of yoga on physical functioning and health related quality of life in older adults: A systematic review and meta-analysis.J Altern Complement Med 18: 902-917.
  30. CheemaBS, Houridis A, Busch L, Raschke-Cheema V, Melville GW, et al. (2013) Effect of an office worksite-based yoga program on heart rate variability: Outcomes of a randomized controlled trial.BMC Complement Altern Med 13: 82.
  31. Melville GW, Chang D, Colagiuri B, Marshall PW, Cheema BS (2012) Fifteen minutes of chair-based yoga postures or guided meditation performed in the office can elicit a relaxation response.Evid Based Complement Alternat Med 2012: 501986.
  32. Martarelli D, Cocchioni M, Scuri S, Pompei P (2011) Diaphragmatic breathing reduces exercise-induced oxidative stress.Evid Based Complement Alternat Med 2011: 932430.
  33. Patil SG, Mullur LM, Khodnapur JP, Dhanakshirur GB, Aithala MR (2013) Effect of yoga on short-term heart rate variability measure as a stress index in sub junior cyclists: A pilot study.Indian J PhysiolPharmacol 57: 153-158.
  34. National Center for Complementary and Alternative Medicine (2014) RFA-AT-14-003: Clinical Trials and Interventional Studies of Non-Pharmacological Approaches to Managing Pain and Co-Morbid Conditions in U.S. Military Personnel, Veterans, and their Families.
  35. Groessl EJ, Weingart KR, Aschbacher K, Pada L, Baxi S (2008) Yoga for veterans with chronic low-back pain.J Altern Complement Med 14: 1123-1129.
  36. Groessl EJ, Weingart KR, Johnson N, Baxi S (2012) The benefits of yoga for women veterans with chronic low back pain.J Altern Complement Med 18: 832-838.
  37. Stoller CC, Greuel JH, Cimini LS, Fowler MS, Koomar JA (2012) Effects of sensory-enhanced yoga on symptoms of combat stress in deployed military personnel.Am J OccupTher 66: 59-68.
  38. Libby DJ, Reddy F, Pilver CE, Desai RA (2012) The use of yoga in specialized VA PTSD treatment programs.Int J Yoga Therap: 79-87.
  39. Sharma VK, Das S, Mondal S, Goswampi U, Gandhi A (2005) Effect of Sahaj Yoga on depressive disorders.Indian J PhysiolPharmacol 49: 462-468.
  40. Granath J, Ingvarsson S, von Thiele U, Lundberg U (2006) Stress management: A randomized study of cognitive behavioural therapy and yoga.CognBehavTher 35: 3-10.
  41. Smith C, Hancock H, Blake-Mortimer J, Eckert K (2007) A randomised comparative trial of yoga and relaxation to reduce stress and anxiety.Complement Ther Med 15: 77-83.
  42. Brazier A, Mulkins A, Verhoef M (2006) Evaluating a yogic breathing and meditation intervention for individuals living with HIV/AIDS.Am J Health Promot 20: 192-195.
  43. Sherman KJ, Cherkin DC, Erro J, Miglioretti DL, Deyo RA (2005) Comparing yoga, exercise, and a self-care book for chronic low back pain: A randomized, controlled trial.Ann Intern Med 143: 849-856.
  44. Williams KA, Petronis J, Smith D, Goodrich D, Wu J, et al. (2005) Effect of Iyengar yoga therapy for chronic low back pain.Pain 115: 107-117.
  45. Groessl EJ,Sklar M, Chang D (2012) Yoga for Low Back Pain: A Review of Concepts and Literature, in Low Back Pain.
  46. Sherman KJ, Cherkin DC, Wellman RD, Cook AJ, Hawkes RJ, et al. (2011) A randomized trial comparing yoga, stretching, and a self-care book for chronic low back pain.Arch Intern Med 171: 2019-2026.
  47. Tilbrook HE, Cox H, Hewitt CE, Kang'ombe AR, Chuang LH, et al. (2011) Yoga for chronic low back pain: a randomized trial.Ann Intern Med 155: 569-578.
  48. Culos-Reed SN, Mackenzie MJ,Sohl SJ, Jesse MT, Zahavich AN, et al. (2012) Yoga and cancer interventions: A review of the clinical significance of patient reported outcomes for cancer survivors. Evid Based Complement Alternat Med642576.
  49. Sadja J, Mills PJ (2013) Effects of yoga interventions on fatigue in cancer patients and survivors: A systematic review of randomized controlled trials.Explore (NY) 9: 232-243.
  50. Posadzki P, Cramer H, Kuzdzal A, Lee MS, Ernst E (2014) Yoga for hypertension: A systematic review of randomized clinical trials.Complement Ther Med 22: 511-522.
  51. Cramer H, Lauche R, Haller H, Steckhan N, Michalsen A, et al. (2014) Effects of yoga on cardiovascular disease risk factors: A systematic review and meta-analysis.Int J Cardiol 173: 170-183.
  52. Hartley L, Dyakova M, Holmes J, Clarke A, Lee MS, et al. (2014) Yoga for the primary prevention of cardiovascular disease.Cochrane Database Syst Rev 5: CD010072.
  53. Cramer H, Posadzki P, Dobos G, Langhorst J (2014) Yoga for asthma: A systematic review and meta-analysis.Ann Allergy Asthma Immunol 112: 503-510.
  54. Katzman MA, Vermani M, Gerbarg PL, Brown RP, Iorio C, et al. (2012) A multicomponent yoga-based, breath intervention program as an adjunctive treatment in patients suffering from generalized anxiety disorder with or without comorbidities.Int J Yoga 5: 57-65.
  55. Cramer H, Lauche R, Klose P, Langhorst J, Dobos G (2013) Yoga for schizophrenia: A systematic review and meta-analysis.BMC Psychiatry 13: 32.
  56. Cramer H, Lauche R, Langhorst J, Dobos G (2013) Yoga for depression: a systematic review and meta-analysis.Depress Anxiety 30: 1068-1083.
  57. Mitchell KS, Dick AM, DiMartino DM, Smith BN, Niles B, et al. (2014) A pilot study of a randomized controlled trial of yoga as an intervention for PTSD symptoms in women.J Trauma Stress 27: 121-128.
  58. van der Kolk BA, Stone L, West J, Rhodes A, Emerson D, et al. (2014) Yoga as an adjunctive treatment for posttraumatic stress disorder: A randomized controlled trial.J Clin Psychiatry 75: e559-565.
  59. Hallgren M, Romberg K, Bakshi AS, Andréasson S (2014) Yoga as an adjunct treatment for alcohol dependence: A pilot study.Complement Ther Med 22: 441-445.
  60. Zhuang SM, An SH, Zhao Y (2013) Yoga effects on mood and quality of life in Chinese women undergoing heroin detoxification: a randomized controlled trial.Nurs Res 62: 260-268.
  61. Pascoe MC, Bauer IE (2015) A systematic review of randomised control trials on the effects of yoga on stress measures and mood.J Psychiatr Res 68: 270-282.
  62. Yoga for the Treatment of Post-Traumatic Stress Disorder, Generalized Anxiety Disorder, Depression, and Substance Abuse: A Review of the Clinical Effectiveness and Guidelines [Internet].
  63. Arias AJ, Steinberg K, Banga A, Trestman RL (2006) Systematic review of the efficacy of meditation techniques as treatments for medical illness.J Altern Complement Med 12: 817-832.
  64. da Silva TL, Ravindran LN, Ravindran AV (2009) Yoga in the treatment of mood and anxiety disorders: A review.Asian J Psychiatr 2: 6-16.
  65. Seppala EM, Nitschke JB,Tudorascu DL, Hayes A, Goldstein MR, et al. (2014) Breathing-based meditation decreases posttraumatic stress disorder symptoms in U.S. military veterans: A randomized controlled longitudinal study. J Trauma Stress 27: 397-405.
  66. Stankovic L (2011) Transforming trauma: A qualitative feasibility study of integrative restoration (iRest) yoga Nidra on combat-related post-traumatic stress disorder.Int J Yoga Therap: 23-37.
  67. Yagli NV, Ulger O (2015) The effects of yoga on the quality of life and depression in elderly breast cancer patients.Complement TherClinPract 21: 7-10.
  68. Bryan S, Pinto Zipp G, Parasher R (2012) The effects of yoga on psychosocial variables and exercise adherence: A randomized, controlled pilot study.AlternTher Health Med 18: 50-59.
  69. Taspinar B, Aslan UB, Agbuga B, Taspinar F (2014) A comparison of the effects of hatha yoga and resistance exercise on mental health and well-being in sedentary adults: A pilot study.Complement Ther Med 22: 433-440.
  70. Quilty MT, Saper RB, Goldstein R, Khalsa SB (2013) Yoga in the Real World: Perceptions, Motivators, Barriers, and patterns of Use.Glob Adv Health Med 2: 44-49.
  71. Holte A, Mills PJ (2013) Yoga and Chronic Illness. In Chronic Illness and Spirituality: Diverse Disciplinary, Religious, and Cultural Perspectives. Michael Stoltzfuy(Ed). Palgrave MacMillan Press 141-164.
  72. Park CL, Riley KE, Bedesin E, Stewart VM (2014) Why practice yoga? Practitioners' motivations for adopting and maintaining yoga practice.J Health Psychol.
  73. Braun TD, Park CL, Conboy LA (2012) Psychological well-being, health behaviors, and weight loss among participants in a residential, Kripalu yoga-based weight loss program.Int J Yoga Therap: 9-22.
  74. Büssing A, Hedtstück A, Khalsa SB, Ostermann T, Heusser P (2012) Development of Specific Aspects of Spirituality during a 6-Month Intensive Yoga Practice.Evid Based Complement Alternat Med 2012: 981523.
  75. Dittmann KA, Freedman MR (2009) Body awareness, eating attitudes, and spiritual beliefs of women practicing yoga.Eat Disord 17: 273-292.
  76. Khalsa SB, Khalsa GS, Khalsa HK, Khalsa MK (2008) Evaluation of a residential Kundalini yoga lifestyle pilot program for addiction in India.J EthnSubst Abuse 7: 67-79.
  77. Khanna S, Greeson JM (2013) A narrative review of yoga and mindfulness as complementary therapies for addiction.Complement Ther Med 21: 244-252.
  78. Luskin F (2004) Transformative practices for integrating mind-body-spirit.J Altern Complement Med 10 Suppl 1: S15-23.
  79. Telles S, Naveen KV, Dash M (2007) Yoga reduces symptoms of distress in tsunami survivors in the andaman islands.Evid Based Complement Alternat M ed 4: 503-509.
Citation: Groessl EJ, Chopra D, Mills PJ (2015) An Overview of Yoga Research for Health and Well-Being. J Yoga Phys Ther 5:210.

Copyright: © 2015 Groessl EJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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