Antihelimentic activity of plant extracts usually consist of phytochemicals component, like flavonoids, alkaloids, tannis, resins, saponins. These all are secondary metabolites. Helminthiasis is among the most important animal diseases inflicting heavy production losses. Helminthiasis one of the most common type of disease in developing countries and produces a global burden of disease. It contributes to the prevalence of malnutrition, anaemia, eosinophilia, and pneumonia. The disease is highly prevalent particularly in third world countries due to poor management practices Helimentiasis is a macroparasitic disease caused by various strains of parasitic worms, known as helimenhs, usually these parasties are tape worms, flukes, and round worms. There are various synthetic drugs, which act as an anthelminthic. However, these days many parasites are resistant to synthetic drugs. As synthetic drugs have high adverse effects, use of phytochemicals as drugs has got good significant importance. Some of the medicinal plants having good anthelminthic activity are Amaranthus spinosus, Amaranthus caudatus and Amaranthus viridis L. these plants belong to family of Amaranthaceae, these plants are traditionally used as verimicides. The roots of these plants were considered to be having high antihelementic activity [1]. Amaranthus viridis is also considered to be having laxative property, besides having antibacterial and antidiabetic activity. The plant is also used traditionally applied as a diuretic, antidiabetic, antipyretic, anti-snake venom, antileprotic and anti-gonorrheal drug.

Some of the other medicinal plants having antihelimentic activity are Clitoria ternatea Linn., Guazuma ulmifolia Lam. and Madhuca indica. Usually all the phytochemicals are extracted by ethanol. Phytochemicals are extracted by using suitable solvent. Solvent are so elected based on their polarity. Solvent with high polarity are selected considered to be desired. Ethanol is most common solvent which is being used for extractions. Besides ethanol, methanol, chloroform are also used. Phytochemicals can also be extracted from water. The process of extraction of desired phytochemicals from water is called decoction [2]. In india, A. caudatus is traditionally used to cure kidney stones, leprosy. Enicostemma littorale is also one of the medicinal plants, which are being used to as an anthelmintic drug. The phytochemcials extracted from various medicinal plants, were being compared to normal conventional synthetic drugs as a reference. Plant extracts with anthelmintic properties are considered one of the most promising alternatives for the control of GIN. Ananas comosus, Aloe ferox, Allium sativum, Lespedeza cuneata and Warburgia salutaris are also some of the medicinal plants, which are more commonly used as anthelmintic. Phytochemicals extracted from Allium sativum is used as antibacterial and also anti helminthic. Allicine is the phytochemical which is present in Allium sativum [3].

Even though pharmacological industries have produced a number of new antibiotics in the last three decades, resistance to these drugs by microorganisms has increased. The problem of microbial resistance is growing and the outlook for the use of antimicrobial drugs in the future is still uncertain. For a long period of time, plants have been a valuable source of natural products for maintaining human health, especially in the last decade, with more intensive studies for natural therapies. The use of plant compounds for pharmaceutical purposes has gradually increased in Brazil. According to World Health Organization medicinal plants would be the best source to obtain a variety of drugs. About 80% of individuals from developed countries use traditional medicine, which has compounds derived from medicinal plants [4] .Therefore, such plants should be investigated to better understand their properties, safety and efficiency.

In general, bacteria have the genetic ability to transmit and acquire resistance to drugs, which are utilized as therapeutic agents. Such a fact is cause for concern, because of the number of patients in hospitals who have suppressed immunity, and due to new bacterial strains, which are multi-resistant. Consequently, new infections can occur in resulting in high mortality some of the medicinal plants having antibacterial activity. Some of the common types of bacterial strains are, Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia. Escherichia coli are a Gram-negative, facultative anaerobic, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms (endotherms) [5,6].

Staphylococcus aureus is a bacterium that is a member of the Firmicutes, and is frequently found in the human respiratory tract and on the skin. Although S. aureus is not always pathogenic, it is a common cause of skin infections (e.g. boils), respiratory disease (e.g. sinusitis), and food. The emergence of antibiotic-resistant forms of pathogenic S. aureus (e.g. MRSA) is a worldwide problem in clinical medicine [7].

Klebsiella is a genus of non-motile, Gram-negative, oxidasenegative, rod-shaped bacteria with a prominent polysaccharidebased capsule. It is named after the German microbiologist Edwin Klebs (1834–1913). Frequent human pathogens, Klebsiella organisms can lead to a wide range of disease states, notably pneumonia, urinary tract infections, septicemia and soft tissue infections [8].

Usually in vitro antimicrobial screening of a medicinal plant is done, by comparing minimum inhibitory concentration of the derived phytochemical with the standard synthetic drug. However, determination of Minimum inhibitory concentration is the primary screening method to analyse the antimicrobial activity. Minimum inhibitory concentration is the initial point in bioprospecting the program. There are many medicinal plants, having anti bactertial activity [9]. Most of them grow in tropical and subtropical regions of the world. Tropical regions include countries like India, Srilanka, Pakistan, and Indonesia. Medicinal plants are abdundant in continent like Africa.

Some of the medicinal plants growing in India are, Justicia adhatoda Zingiber offcininale, Allium sativum, Embilica officinalis, Lawsonia inermis, Ocimum sanctum, Myristica fragrans, Rauwolfia serpentine Lawsonia inermis. Besides all these, honey a natural extract is also a good antibacterial. The antibacterial potency of all the above medicinal plants, and their extracts were been reported in several studies and also were been used since, ancient days. Phytochemical from medicinal plants is being extracted by using various solvents like ethanol, methanol, chloroform, and some time aqueous extracts is also done [10]. The selection of solvent is done according to the polarity of the solvent, and phytochemical desired to be extracted. Phytochemical which play a major role as antibacterial are Zingiberne in Zingiber offcininale, allicine in Allium sativum, galic acid in Embilica officinalis, lawsone in Lawsonia inermis, eugenol in Ocimum sanctum, Myristine in Myristica fragrans, Reserpine in Rauwolfia serpentine Lawsone in Lawsonia inermis. The antibacterial potential of these phytochemicals varies from genus, parts of plant being extracted, and method involved in extraction. Honey is produced from various floral sources, and its anti-bacterial activity also varies from origin and its processing. It’s been used as natural antiseptic since ancient days [11,12]. The concentration of its antibacterial activity differs from the bacterial species and strain of bacteria. The antibacterial activity of honey is usually associated with its pH, sugar content, and its high osmolarity. The higher the sugar content present in honey, the greater is its antibacterial efficiency. Similarly higher the osmolality greater is the efficiency of its antibacterial activity. Honey also acts as an antioxidant besides antibacterial.

Plants are one of the important sources for many medicinal drugs. Various phytochemicals extracted, could act as anticancer, antimicrobial, antioxidant, ant inflammatory, however as there are many pharmacological industries which have produce many drugs a number, resistance to these drugs has increased. Hence, importance of Phytochemicals has been recognized.