Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

Benefits and Risks Involved in Intra-Cytoplasmic Sperm Injection (ICSI) Procedure

Sukanya Hervik^{* *}Correspondence: Sukanya Hervik, Department of Obstetrics and Gynecology, Khon Kaen University, Khon Kaen, Thailand, Email:

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Description

In order to increase the chances of conceiving, Intra-Cytoplasmic Sperm Injection (ICSI) is the most selected and dependable advanced approach for In Vitro Fertilization (IVF). ICSI involves injection of sperm directly inside the egg of the women to achieve fertilization outside the body. This advanced IVF approach is ideal for the cases where the ideal fertilization atmosphere is unattainable inside the mother. According to the medical professionals, success rate of IVF i.e. ICSI is relatively high which makes it extensively trusted and dependable. Intra- Cytoplasmic Sperm Injection is recommended for couple’s who have been diagnosed with manly fertility issues such as by increasing the number of fertilized eggs available for transfer or freezing, low sperm count, low sperm morphology or motility, anti-sperm antibodies or have previously had a vasectomy or ineffective vasectomy reversal. We can also use this approach for couples who have endured poor or no fertilization rates using standard IVF.

Physicians perform the ICSI procedure with IVF, which involves administering a sperm sample directly into a mature egg. During this procedure, the physician inserts a small glass tube (holding a single sperm) into one egg. The physician also examines the eggs the coming day to check if it’s successfully fertilized or not. Fertilized eggs are left to mature for several incorporating, at which point they become multicellular embryos. Physicians use these embryos for the embryo transfer procedure (incorporating an embryo into a woman’s uterus). Most embryo transfers are now or Frozen Embryo Transfers (FETs), meaning the embryos are re-frozen and further thawed before transfer. This allows adaptability on timeline, and depending on the patient, it can lead to improved success rates than a Fresh Embryo Transfer. Intended parents have the option to freeze and store any remaining high quality embryos for future use.

Benefits of ICSI

Men who have sperm motility issues, critically low sperm count, who have problems associated with sperm development, men with blockage that prevents sperm from being ejected (similar as a vasectomy), those looking to maximize the number of highquality embryos created from one egg retrieval. Couples that haven't been successful with previous IVF attempts may profit from ICSI, also couples that wish to test for certain inheritable problems frequently make good applicants for ICSI treatment.

Risks involved in ICSI

While ICSI can significantly increase the chances of a successful conceiving during IVF cycles, there are several threats intended parents must consider before choosing to experience this procedure. The ICSI procedure has the possibility of damaging the eggs due to needle insertion, and the overall threat of having a baby with chromosomal abnormalities is 0.08% births. This may also lead to an increased threat of abortion, heart problems, increased threat of behavior or learning disabilities, or indeed increased threat of infertility in the child during adultness. Because of these risks, it’s important to choose a fertility clinic that has little to no experience with these side effects and pick a experienced physician.

Certain conditions have been associated with the use of ICSI, like as Beckwith-Wiedemann syndrome, Angelman syndrome, hypospadias, or sexual intercourse chromosome abnormalities. But these abnormalities occur in very low proportion in children born using ICSI approach. Some of the problems that cause infertility may be inheritable. For example, the children who born through ICSI approach may suffer from the infertility issues similar to their fathers.

Conclusion

The initiation of ICSI has changed in a revolutionary way the world of assisted reproduction technology allowing us to efficiently treat patients with oligoasthenoteratozoospermia, testicular spermatozoa, limited number of oocytes, former IVF failures. ICSI has replaced all previous assisted fertilization techniques. ICSI can help couples who have struggled with impotence. The main benefit of ICSI during IVF is an enhanced fertilization rate, which can increase the number of fertilized eggs available for transfer or freezing and can also increase the chances for a successful fertilization under normal insemination such as Intra Uterine Insemination (IUI).