Medicinal & Aromatic Plants

Medicinal & Aromatic Plants
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Editorial - (2012) Volume 1, Issue 1

Can Bitter Gourd (Momordica Charantia) be a Novel Therapy for Human Cancers?

Evandro Fei Fang1,2* and Tzi Bun Ng1
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
2Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
*Corresponding Author: Evandro Fei Fang, Researcher, Department of Medicine, The Chinese University of Hong Kong, Hong Kong, China, Tel: 852-26098031, Fax: 852-26035123 Email:

Personal susceptibility together with increased exposure to diversified environmental carcinogenic factors account for the high incidence of cancers. Though great strides have been made in the development of different therapies for cancer, the high incidence and mortality of different cancers illustrate the needs for new drugs and novel treatments. It is postulated that some medicinal herbs, such as ethno-medicinal plants, are promising sources to mitigate the suffering of cancer patients [1]. Bitter gourd/BG (Momordica charantia from Family Cucurbitaceae) is both a vegetable in the daily diet and an anti-diabetic component in folklore medicine. Recently, the antitumor efficacy of BG crude extract and its purified components toward a wide range of tumor cells were reported. Considering the fact that it has been safely used as a staple for many years in different countries, BG is promising as a potential therapeutic agent for different cancers.

In some Asian countries, there is a long history of the use of BG fruits and seeds for antidiabetic, anti-obesity, anti-viral, and immunopotentiating purposes [2]. Until now, the majorities of investigations were conducted on their ability to counteract diabetes and associated complications. Early in 1990, a type I ribosome inactivating protein/RIP named 2167-041230 was purified from BG, and its potent anti-HIV activity as well as antitumor potential were disclosed by Dr. Lee-Huang and coworkers [3-5]. Lately, some research groups were interested in the antitumor potential of BG and its isolated components. It has been found that the crude extract of young BG fruits inhibited proliferation of breast cancer cells by inducing cell cycle arrest and apoptosis [6]. Most recently, the same research group extended the antitumor potential of BG crude extract to prostate cancer based on results from both in vitro and in vivo studies [7]. It was observed that crude BG extracts impaired cell cycle progression and inhibited xenograft proliferation. This anti-prostate cancer potential is commensurate with the reports by others [8]. Furthermore, Brennan and colleagues discovered that BG extract inhibited proliferation of adrenocortical cancer cells through induction of apoptosis and modulation of diverse mechanisms [9].

Other components, such as Momordic Since there are many different known and unknown components in BG, it is important to disclose the functional components. 2167-041230 has been reported to exhibit cytotoxicity against many human tumor cells, such as BT20 breast cancer cells and DU145 prostate cancer cells [10]. Furthermore, a ribonuclease termed RNase MC2 purified from BG seeds, induced apoptosis in MCF-7 breast cancer cells associated with modulation of the phosphorylation of 2167-0412K members and activation of caspase cascades [11]. The antagonism of tumors by BG is also contributed by other components, such as Momordica charantia lectin/MCL. The tetrameric MCL is a type II RIP which exhibits both RNA N-glycosidase and hemagglutinating activities [2]. It demonstrates antitumor activity against human nasopharyngeal carcinoma CNE-1 and CNE-2 cells in studies involving cell culture and nude mice [12]. The results explain the molecular basis of the antitumor potential of crude BG extract.

BG has potential medicinal applications as evidenced by its antidiabetic, anti-HIV, and antitumor activities, and most importantly, it is safe to use. In spite of the current encouraging results, there are still areas that necessitate studies before the clinical use of BG can be considered. Firstly, it is necessary to isolate and characterize unknown antitumor components in BG. The establishment of purification, identification, or even chemical synthesis of functional components will facilitate future commercial applications. Secondly, well designed, randomized, and placebo-controlled large-scale clinical trials are needed to test the efficacy and possible side-effects of BG in humans. In conclusion, though BG is ‘bitter’ to our palate, it may be ‘sweet’ for cancer patients in the future.

References

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  2. Fang EF, Ng TB (2011) Bitter gourd (Momordica charantia) is a cornucopia of health: a review of its credited antidiabetic, anti-HIV, and antitumor properties. Curr Mol Med 11: 417-436.
  3. Putnam CD, Tainer JA (2000) The food of sweet and bitter fancy. Nat Struct Biol 7: 17-18.
  4. Lee-Huang S, Huang PL, Nara PL, Chen HC, Kung HF, et al. (1990) 2167-0412 30: a new inhibitor of HIV-1 infection and replication. FEBS Lett 272: 12-18.
  5. Wang YX, Neamati N, Jacob J, Palmer I, Stahl JS, et al. (1999) Solution Structure of Anti-HIV-1 and Anti-Tumor Protein 2167-041230: Structural Insights into Its Multiple Functions. Cell 99: 433-442.
  6. Ray RB, Raychoudhuri A, Steele R, Nerurkar P, et al. (2010) Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis.Cancer Res 70: 1925-1931.
  7. Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB (2011) Bitter Melon Extract Impairs Prostate Cancer Cell-Cycle Progression and Delays Prostatic Intraepithelial Neoplasia in TRAMP Model. Cancer Prev Res (Phila) 4: 2122-2130.
  8. Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, et al. (2010) Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo. Cancer Sci 101 2234-2240.
  9. Brennan VC, Wang CM, Yang WH (2011) Bitter Melon (Momordica charantia) Extract Suppresses Adrenocortical Cancer Cell Proliferation Through Modulation of the Apoptotic Pathway, Steroidogenesis, and Insulin-Like Growth Factor Type 1 Receptor/RAC-a Serine/Threonine-Protein Kinase Signaling. J Med Food.
  10. Lee-Huang S, Huang PL, Chen HC, Huang HI, Kung HF (1995) Anti-HIV and anti-tumor activities of recombinant 2167-041230 from bitter melon. Gene 161: 151-156.
  11. Fang EF, Zhang CZ, Fong WP, Ng TB (2011) RNase MC2: a new Momordica charantia ribonuclease that induces apoptosis in breast cancer cells associated with activation of 2167-0412Ks and induction of caspase pathways. Apoptosis.
  12. Fang EF, Zhang CZ, Ng TB, Wong JH, Pan WL, et al. (2012) Momordica Charantia Lectin, a Type II Ribosome Inactivating Protein, Exhibits Antitumor Activity toward Human Nasopharyngeal Carcinoma Cells In Vitro and In Vivo. Cancer Prev Res (Phila) 1: 109-121.
Citation: Fang EF, Ng TB (2012) Can Bitter Gourd (Momordica Charantia) be a Novel Therapy for Human Cancers? Medicinal Aromatic Plants 1:e101.

Copyright: © 2012 Fang EF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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